The human pain system exhibits higher-order plasticity (metaplasticity)
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2018.04.003
Abstract: HIGHLIGHTSPainful high frequency stimulation induces long‐term potentiation of pain (pain‐LTP).A very low frequency conditioning protocol prevents the development of pain‐LTP.A very low frequency conditioning protocol reverses an already established pain‐LTP.Findings may lead to effective prevention… read more here.
Keywords: pain ltp; system; human pain; frequency ... See more keywords
Distinct clusters of human pain gene orthologs in Caenorhabditis elegans regulate thermo-nociceptive sensitivity and plasticity
Sign Up to like & getrecommendations! Published in 2023 at "Genetics"
DOI: 10.1093/genetics/iyad047
Abstract: Abstract The detection and avoidance of harmful stimuli are essential animal capabilities. The molecular and cellular mechanisms controlling nociception and its plasticity are conserved, genetically controlled processes of broad biomedical interest given their relevance to… read more here.
Keywords: pain gene; human pain; plasticity; caenorhabditis elegans ... See more keywords
Human pain ratings to electrical sinusoids increase with cooling through a cold-induced increase in C-fibre excitability.
Sign Up to like & getrecommendations! Published in 2023 at "Pain"
DOI: 10.1097/j.pain.0000000000002849
Abstract: ABSTRACT Low-frequency sinusoidal current applied to human skin evokes local axon reflex flare and burning pain, indicative of C-fibre activation. Because topical cooling works well as a local analgesic, we examined the effect of cooling… read more here.
Keywords: ratings electrical; increase; fibre; human pain ... See more keywords