Isobaric Labeling-Based LC-MS/MS Strategy for Comprehensive Profiling of Human Pancreatic Tissue Proteome.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/7651_2017_77
Abstract: The pancreas is an organ with both endocrine and exocrine functions, and various pathologies, such as pancreatic cancer and diabetes are associated with this organ. Owing to the limited pancreatic biopsy samples available for research,… read more here.
Keywords: tissue proteome; pancreatic tissue; tissue; human pancreatic ... See more keywords
Persistent coxsackievirus B4 infection induces microRNA dysregulation in human pancreatic cells
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-017-2567-0
Abstract: Enterovirus infections are implicated in the development of type 1 diabetes (T1D). MicroRNAs as regulators of gene expression are involved in many physiological and pathological processes. Given that viral infections dysregulate cellular microRNAs, we investigated… read more here.
Keywords: persistent coxsackievirus; human pancreatic; expression; coxsackievirus infection ... See more keywords
Reduced expression of annexin A1 promotes gemcitabine and 5-fluorouracil drug resistance of human pancreatic cancer
Sign Up to like & getrecommendations! Published in 2019 at "Investigational New Drugs"
DOI: 10.1007/s10637-019-00785-5
Abstract: Intrinsic chemoresistance is the main reason for the failure of human pancreatic ductal adenocarcinoma (PDAC) therapy. To identify the candidate protein, we compared the protein expression profiling of PDAC cells and its distinct surviving cells… read more here.
Keywords: expression annexin; reduced expression; drug; human pancreatic ... See more keywords
Association of Jagged1 expression with malignancy and prognosis in human pancreatic cancer
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DOI: 10.1007/s13402-020-00527-3
Abstract: Purpose Pancreatic cancer is one of the most aggressive cancers. Preclinical and clinical data indicate that Notch 1 ligand jagged1 (JAG1) plays a pro-oncogenic role in several malignant cancers. As yet, however, the role of… read more here.
Keywords: jag1 silencing; pancreatic cancer; human pancreatic; expression ... See more keywords
HNF4alpha expression amplifies the glucocorticoid-induced conversion of a human pancreatic cell line to an hepatocyte-like cell.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.07.092
Abstract: The pancreas and liver are closely related developmentally and trans-differentiation of cells from one tissue into the cells of the other has been documented to occur after injury or exposure to selected growth factors or… read more here.
Keywords: cell; hepatocyte like; line; human pancreatic ... See more keywords
Murine and human pancreatic tumor exosome recovery in mouse serum: Diagnostic and prognostic potential and target cell delivery.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.06.005
Abstract: Exosomes (Exo), powerful intercellular communicators, are recovered in all body fluids, suggesting suitability for diagnosis and prognosis. Easy in vitro manipulation recommends Exo as drug vehicles. Aiming to consolidate diagnostic and therapeutic potential of Exo, we… read more here.
Keywords: recovery; serum; human pancreatic; potential ... See more keywords
TIGER: The gene expression regulatory variation landscape of human pancreatic islets.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109807
Abstract: Genome-wide association studies (GWASs) identified hundreds of signals associated with type 2 diabetes (T2D). To gain insight into their underlying molecular mechanisms, we have created the translational human pancreatic islet genotype tissue-expression resource (TIGER), aggregating… read more here.
Keywords: variation; islet; human pancreatic; expression ... See more keywords
Combined Omics Approaches Reveal the Roles of Non-canonical WNT7B Signaling and YY1 in the Proliferation of Human Pancreatic Progenitor Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2020.08.018
Abstract: The proliferation of human pancreatic progenitor cells (PPCs) is critical for developing cell therapies for diabetes. Here, using transcriptome analysis combined with small interfering RNA (siRNA) screening, we revealed that WNT7B is a downstream growth… read more here.
Keywords: wnt7b; proliferation; human pancreatic; non canonical ... See more keywords
Functional Characterization of Native, High-Affinity GABAA Receptors in Human Pancreatic β Cells
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DOI: 10.1016/j.ebiom.2018.03.014
Abstract: In human pancreatic islets, the neurotransmitter γ-aminobutyric acid (GABA) is an extracellular signaling molecule synthesized by and released from the insulin-secreting β cells. The effective, physiological GABA concentration range within human islets is unknown. Here… read more here.
Keywords: affinity; human pancreatic; gabaa receptors; gaba ... See more keywords
Vanadium(V) tris-3,5-di-tert-butylcatecholato complex: Links between speciation and anti-proliferative activity in human pancreatic cancer cells.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2019.110815
Abstract: Vanadium complexes are intensively tested for anti-cancer activities, particularly for the novel treatment protocols involving injections of cytotoxic compounds directly into the tumor. This approach is increasingly applied to difficult-to-treat cancers, such as pancreatic cancer.… read more here.
Keywords: anti proliferative; pancreatic cancer; human pancreatic; nh4 dtbc ... See more keywords
Modeling human pancreatic beta cell dedifferentiation
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DOI: 10.1016/j.molmet.2018.02.002
Abstract: Objective Dedifferentiation could explain reduced functional pancreatic β-cell mass in type 2 diabetes (T2D). Methods Here we model human β-cell dedifferentiation using growth factor stimulation in the human β-cell line, EndoC-βH1, and human pancreatic islets.… read more here.
Keywords: fgf2; cell dedifferentiation; human pancreatic; expression ... See more keywords