Human parainfluenza virus type 2 V protein inhibits induction of tetherin
Sign Up to like & getrecommendations! Published in 2017 at "Medical Microbiology and Immunology"
DOI: 10.1007/s00430-017-0508-z
Abstract: Tetherin is an anti-viral factor that restricts viral budding through tethering virions to the cell surface. The human parainfluenza virus type 2 (hPIV-2) V protein decreases cell surface tetherin in HeLa cells, which constitutively express… read more here.
Keywords: protein; human parainfluenza; tetherin; infection ... See more keywords
New antiviral approaches for human parainfluenza: Inhibiting the haemagglutinin-neuraminidase.
Sign Up to like & getrecommendations! Published in 2019 at "Antiviral research"
DOI: 10.1016/j.antiviral.2019.04.001
Abstract: Human parainfluenza viruses cause acute respiratory tract infections and disease predominantly in young children and immunocompromised individuals. Currently, there are no vaccines to prevent hPIV infections, nor licensed anti-hPIV drugs. There is therefore a need… read more here.
Keywords: human parainfluenza; new antiviral; haemagglutinin neuraminidase; antiviral approaches ... See more keywords
Human parainfluenza virus surveillance in pediatric patients with lower respiratory tract infections: a special view of parainfluenza type 4.
Sign Up to like & getrecommendations! Published in 2018 at "Jornal de pediatria"
DOI: 10.1016/j.jped.2017.07.017
Abstract: OBJECTIVE Characterize the role of human parainfluenza virus and its clinical features in Brazilian children under 2 years of age presenting with acute lower respiratory tract infections. METHODS Real-time assays were used to identify strains… read more here.
Keywords: lower respiratory; human parainfluenza; respiratory tract; parainfluenza virus ... See more keywords
Peripheral blood T cells response in human parainfluenza virus-associated lower respiratory tract infection in children
Sign Up to like & getrecommendations! Published in 2020 at "Saudi Journal of Biological Sciences"
DOI: 10.1016/j.sjbs.2020.07.005
Abstract: Human Parainfluenza virus (HPIV) causes lower respiratory tract infections (LRTI) mostly in young children. Respiratory viral infections may decline T cells in circulation and display enhanced pathogenicity. This study is aimed to analyze T cells… read more here.
Keywords: lower respiratory; human parainfluenza; cd8; parainfluenza virus ... See more keywords
Design, Synthesis, and Antiviral Evaluation of Sialic Acid Derivatives as Inhibitors of Newcastle Disease Virus Hemagglutinin-Neuraminidase: A Translational Study on Human Parainfluenza Viruses
Sign Up to like & getrecommendations! Published in 2023 at "ACS Infectious Diseases"
DOI: 10.1021/acsinfecdis.2c00576
Abstract: Global infections with viruses belonging to the Paramyxoviridae, such as Newcastle disease virus (NDV) or human parainfluenza viruses (hPIVs), pose a serious threat to animal and human health. NDV-HN and hPIVs-HN (HN hemagglutinin-neuraminidase) share a… read more here.
Keywords: newcastle disease; hemagglutinin neuraminidase; parainfluenza viruses; human parainfluenza ... See more keywords
A versatile platform technology for recombinant vaccines using non-propagative human parainfluenza virus type 2 vector
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-49579-y
Abstract: Ectopic protein with proper steric structure was efficiently loaded onto the envelope of the F gene-defective BC-PIV vector derived from human parainfluenza virus type 2 (hPIV2) by a reverse genetics method of recombinant virus production.… read more here.
Keywords: vector; human parainfluenza; virus type; parainfluenza virus ... See more keywords
Seroprevalence of Human Parainfluenza Virus Types 1-4 Among Healthy Children Under 5 Years of Age in Korea.
Sign Up to like & getrecommendations! Published in 2018 at "Viral Immunology"
DOI: 10.1089/vim.2017.0154
Abstract: Abstract Human parainfluenza viruses (HPIVs) are among the major causes of respiratory infections in children, worldwide, including in Korea. There are four types of HPIVs, each with different epid... read more here.
Keywords: human parainfluenza; virus types; parainfluenza virus; seroprevalence human ... See more keywords
Evaluation of a live-attenuated human parainfluenza virus type 2 vaccine in adults and children.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the Pediatric Infectious Diseases Society"
DOI: 10.1093/jpids/piac137
Abstract: We conducted a phase I clinical trial of the live-attenuated recombinant human parainfluenza virus type 2 (HPIV2) vaccine candidate rHPIV2-15C/948L/∆1724 sequentially in adults, HPIV2-seropositive children, and HPIV2-seronegative children, the target population for vaccination. rHPIV2-15C/948L/∆1724 was… read more here.
Keywords: parainfluenza virus; human parainfluenza; live attenuated; virus type ... See more keywords
Epidemiology and seasonality of human parainfluenza serotypes 1‐3 in Australian children
Sign Up to like & getrecommendations! Published in 2021 at "Influenza and Other Respiratory Viruses"
DOI: 10.1111/irv.12838
Abstract: Parainfluenza viruses are significant contributors to childhood respiratory illness worldwide, although detailed epidemiological studies are lacking. Few recent Australian studies have investigated serotype‐specific PIV epidemiology, and there is a paucity of southern hemisphere PIV reports.… read more here.
Keywords: human parainfluenza; epidemiology; seasonality human; epidemiology seasonality ... See more keywords
Modeling Infection and Tropism of Human Parainfluenza Virus Type 3 in Ferrets
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.03831-21
Abstract: HPIV-3 is an important cause of pediatric disease and significantly impacts the elderly. Increasing numbers of immunocompromised patients suffer from HPIV-3 infections, often related to problems with viral clearance. ABSTRACT Human parainfluenza virus type 3… read more here.
Keywords: parainfluenza virus; infection; hpiv infections; human parainfluenza ... See more keywords
In Silico Prediction And Evaluation of Human Parainfluenza Virus-3 CD4+ T Cell Epitopes.
Sign Up to like & getrecommendations! Published in 2022 at "Current computer-aided drug design"
DOI: 10.2174/1573409919666221205122633
Abstract: BACKGROUND Human parainfluenza viruses type 3 (HPIV-3) through bronchiolitis and pneumonia is a common cause of lower respiratory tract infections. It is the main cause of hospitalization of infants and young children and also one… read more here.
Keywords: human parainfluenza; hpiv; cd4 cell;