The Emerging Role of Epigenetic Mechanisms in the Causation of Aberrant MMP Activity during Human Pathologies and the Use of Medicinal Drugs
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DOI: 10.3390/biom11040578
Abstract: Matrix metalloproteinases (MMPs) cleave extracellular matrix proteins, growth factors, cytokines, and receptors to influence organ development, architecture, function, and the systemic and cell-specific responses to diseases and pharmacological drugs. Conversely, many diseases (such as atherosclerosis,… read more here.
Keywords: emerging role; mmp; human pathologies; epigenetic mechanisms ... See more keywords
Network-Based Methods for Approaching Human Pathologies from a Phenotypic Point of View
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DOI: 10.3390/genes13061081
Abstract: Network and systemic approaches to studying human pathologies are helping us to gain insight into the molecular mechanisms of and potential therapeutic interventions for human diseases, especially for complex diseases where large numbers of genes… read more here.
Keywords: network; network based; approaching human; based methods ... See more keywords
Metals and Metal-Nanoparticles in Human Pathologies: From Exposure to Therapy
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DOI: 10.3390/molecules26216639
Abstract: An increasing number of pathologies correlates with both toxic and essential metal ions dyshomeostasis. Next to known genetic disorders (e.g., Wilson’s Disease and β-Thalassemia) other pathological states such as neurodegeneration and diabetes are characterized by… read more here.
Keywords: metal nanoparticles; nanoparticles human; metal ions; human pathologies ... See more keywords