Role of IGF-1R in epithelial–mesenchymal transdifferentiation of human peritoneal mesothelial cells
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Nephrology"
DOI: 10.1007/s10157-022-02209-w
Abstract: Peritoneal fibrosis (PF) is caused by epithelial-mesenchymal transdifferentiation (EMT) in the peritoneum under high glucose (HG) conditions. The study aimed to explored the role of Insulin-like growth factor 1 receptor (IGF-1R) in the regulation of… read more here.
Keywords: mesenchymal transdifferentiation; human peritoneal; peritoneal mesothelial; mesothelial cells ... See more keywords
AGEs induce epithelial to mesenchymal transformation of human peritoneal mesothelial cells via upregulation of STAT3
Sign Up to like & getrecommendations! Published in 2019 at "Glycoconjugate Journal"
DOI: 10.1007/s10719-019-09861-7
Abstract: Epithelial-mesenchymal transition (EMT) in peritoneum was induced during peritoneal dialysis (PD), which finally caused progressive fibrosis. However, the underlying mechanisms were not well elucidated. We established advanced glycation end-products (AGEs)-induced EMT model using primary human… read more here.
Keywords: human peritoneal; ages induce; stat3; mesothelial cells ... See more keywords
Telomere length profiles in primary human peritoneal mesothelial cells are consistent with senescence
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Ageing and Development"
DOI: 10.1016/j.mad.2017.03.010
Abstract: Mesothelial cell (MC) senescence contributes to malignancy and tissue fibrosis. The role of telomere erosion in MC senescence remains controversial, with evidence for both telomere-dependent and telomere-independent mechanisms reported. Single telomere length analysis revealed considerable… read more here.
Keywords: human peritoneal; telomere length; senescence; cells consistent ... See more keywords
Characterization of human peritoneal monocyte/macrophage subsets in homeostasis: Phenotype, GATA6, phagocytic/oxidative activities and cytokines expression
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-30787-x
Abstract: Peritoneal macrophages play a critical role in the control of infectious and inflammatory diseases. Although recent progress on murine peritoneal macrophages has revealed multiple aspects on their origin and mechanisms involved in their maintenance in… read more here.
Keywords: human peritoneal; peritoneal macrophages; cd14 cd16; expression ... See more keywords
Angiotensin II type 2 receptor prevents extracellular matrix accumulation in human peritoneal mesothelial cell by ameliorating lipid disorder via LOX‐1 suppression
Sign Up to like & getrecommendations! Published in 2022 at "Renal Failure"
DOI: 10.1080/0886022x.2022.2133729
Abstract: Abstract Evidence suggests that intracellular angiotensin II type 1 receptor (AT1) contributes to peritoneal fibrosis (PF) under high glucose (HG)-based dialysates. It is generally believed that AT2 antagonisticly affects AT1 function. The aim of this… read more here.
Keywords: ecm; angiotensin type; accumulation; human peritoneal ... See more keywords
Mammalian Target of Rapamycin Complex 1 Activation Disrupts the Low-Density Lipoprotein Receptor Pathway: A Novel Mechanism for Extracellular Matrix Accumulation in Human Peritoneal Mesothelial Cells
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Nephrology"
DOI: 10.1159/000494144
Abstract: Peritoneal fibrosis (PF) is characterized by progressive extracellular matrix (ECM) accumulation. Increasing evidence has suggested that ECM synthesis was increased in human peritoneal mesothelial cells (HPMCs) under high-glucose conditions, but the effects of high-glucose peritoneal… read more here.
Keywords: human peritoneal; accumulation; pds; extracellular matrix ... See more keywords
Long-term peritoneal dialysate exposure modulates expression of membrane complement regulators in human peritoneal mesothelial cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.972592
Abstract: The membrane complement regulators (CRegs) CD46, CD55, and CD59 are highly expressed on human peritoneal mesothelial cells. However, how mesothelial CRegs change according to the peritoneal dialysis (PD) history of patients has remained unclear. We… read more here.
Keywords: pdf; peritoneal mesothelial; mesothelial cells; membrane complement ... See more keywords
Polyphenols Attenuate Highly-Glycosylated Haemoglobin-Induced Damage in Human Peritoneal Mesothelial Cells
Sign Up to like & getrecommendations! Published in 2020 at "Antioxidants"
DOI: 10.3390/antiox9070572
Abstract: We investigated the cytoprotective role of the dietary polyphenols on putative damage induced by Amadori adducts in Human Peritoneal Mesothelial Cells (HPMCs). Increased accumulation of early products of non-enzymatic protein glycation—Amadori adducts—in the peritoneal dialysis… read more here.
Keywords: human peritoneal; amadori adducts; mesothelial cells; peritoneal dialysis ... See more keywords