In silico predictions of the human pharmacokinetics/toxicokinetics of 65 chemicals from various classes using conformal prediction methodology
Sign Up to like & getrecommendations! Published in 2022 at "Xenobiotica"
DOI: 10.1080/00498254.2022.2049397
Abstract: Abstract Pharmacokinetic/toxicokinetic (PK/TK) information for chemicals in humans is generally lacking. Here we applied machine learning, conformal prediction and a new physiologically-based PK/TK model for prediction of the human PK/TK of 65 chemicals from different… read more here.
Keywords: silico predictions; methodology; human pharmacokinetics; conformal prediction ... See more keywords
Prediction of human pharmacokinetics of Fc-engineered therapeutic monoclonal antibodies using human FcRn transgenic mice
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DOI: 10.1080/19420862.2025.2484443
Abstract: ABSTRACT Human FcRn transgenic mice (Tg32) have been widely used to evaluate the pharmacokinetics of mAbs and predict human pharmacokinetics. This study aims to establish an approach for predicting the human pharmacokinetics of Fc-engineered mAbs… read more here.
Keywords: human fcrn; mice; engineered mabs; human pharmacokinetics ... See more keywords
Prediction of Human Pharmacokinetics of Antibody–Drug Conjugates From Nonclinical Data
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DOI: 10.1111/cts.12649
Abstract: Prediction of human pharmacokinetics (PK) based on preclinical information for antibody–drug conjugates (ADCs) provide important insight into first‐in‐human (FIH) study design. This retrospective analysis was conducted to identify an appropriate scaling method to predict human… read more here.
Keywords: allometric scaling; human pharmacokinetics; prediction human; antibody drug ... See more keywords