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Published in 2022 at "Xenobiotica"
DOI: 10.1080/00498254.2022.2049397
Abstract: Abstract Pharmacokinetic/toxicokinetic (PK/TK) information for chemicals in humans is generally lacking. Here we applied machine learning, conformal prediction and a new physiologically-based PK/TK model for prediction of the human PK/TK of 65 chemicals from different…
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Keywords:
silico predictions;
methodology;
human pharmacokinetics;
conformal prediction ... See more keywords
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Published in 2019 at "Clinical and Translational Science"
DOI: 10.1111/cts.12649
Abstract: Prediction of human pharmacokinetics (PK) based on preclinical information for antibody–drug conjugates (ADCs) provide important insight into first‐in‐human (FIH) study design. This retrospective analysis was conducted to identify an appropriate scaling method to predict human…
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Keywords:
allometric scaling;
human pharmacokinetics;
prediction human;
antibody drug ... See more keywords