Human Piezo1 Membrane Localization and Gating Kinetics are Modulated by Cholesetrol Levels
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DOI: 10.1016/j.bpj.2016.11.2883
Abstract: The human mechanosensitive ion channel Piezo1 gates in response to membrane tension and regulates essential biological processes such as vascular development and erythrocyte volume homeostasis. Currently little is known regarding theplasma membrane localization and organization… read more here.
Keywords: piezo1 membrane; membrane localization; human piezo1; membrane ... See more keywords
Functional analyses of heteromeric human PIEZO1 Channels
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DOI: 10.1371/journal.pone.0207309
Abstract: PIEZO1 and PIEZO2 are mechanosensitive channels (MSCs) important for cellular function and mutations in them lead to human disorders. We examined how functional heteromers form between subunits of PIEZO1 using the mutants E2117K, E2117D, and… read more here.
Keywords: piezo1 channels; functional analyses; piezo1; human piezo1 ... See more keywords