An Optimized Human Erythroblast Differentiation System Reveals Cholesterol‐Dependency of Robust Production of Cultured Red Blood Cells Ex Vivo
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202303471
Abstract: The generation of cultured red blood cells (cRBCs) ex vivo represents a potentially unlimited source for RBC transfusion and other cell therapies. Human cRBCs can be generated from the terminal differentiation of proliferating erythroblasts derived… read more here.
Keywords: differentiation; human plasma; cultured red; red blood ... See more keywords
High‐throughput immunoaffinity enrichment and N‐glycan analysis of human plasma haptoglobin
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28280
Abstract: Haptoglobin (Hp) is a positive acute phase protein, synthesized in the liver, with four N‐glycosylation sites carrying mainly complex type N‐glycans. Its glycosylation is altered in different types of diseases but still has not been… read more here.
Keywords: high throughput; analysis; human plasma; immunoaffinity ... See more keywords
The soluble cytoplasmic tail of CD45 (ct‐CD45) in human plasma contributes to keep T cells in a quiescent state
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201646405
Abstract: The cytoplasmic tail of CD45 (ct‐CD45) is proteolytically cleaved and released upon activation of human phagocytes. It acts on T cells as an inhibitory, cytokine‐like factor in vitro. Here, we show that ct‐CD45 is abundant… read more here.
Keywords: plasma; cd45 cd45; human plasma; cytoplasmic tail ... See more keywords
A Micro‐Flow Liquid Chromatography–Mass Spectrometry Method for the Quantification of Oxylipins in Volume‐Limited Human Plasma
Sign Up to like & getrecommendations! Published in 2024 at "Electrophoresis"
DOI: 10.1002/elps.202400151
Abstract: Oxylipins are well‐known lipid mediators in various inflammatory conditions. Their endogenous concentrations range from low picomolar to nanomolar, and there are growing demands to determine their concentrations in low‐volume matrices for pathological studies, including blood,… read more here.
Keywords: human plasma; method; quantification; volume ... See more keywords
Multiple Epitopes of Hepatitis B Virus Surface Antigen Targeted by Human Plasma-derived Immunoglobulins Coincide with Clinically Observed Escape Mutations.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medical virology"
DOI: 10.1002/jmv.27278
Abstract: Hepatitis B Immune Globulin (HBIG) is a human plasma-derived IgG concentrate that contains a high titer of neutralizing antibodies (anti-HBs) to the hepatitis B virus (HBV) surface antigen (HBsAg). HBIG is known to be highly… read more here.
Keywords: surface antigen; human plasma; anti hbs; site ... See more keywords
Two HPLC-MS/MS methods for determination of edaravone and taurine in human plasma: Application to drug-drug interaction and pharmacokinetic studies.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of separation science"
DOI: 10.1002/jssc.201901322
Abstract: Two HPLC-MS/MS methods were developed and validated for the quantification of edaravone (method A) or taurine (method B) in human plasma. After protein precipitation, separations were achieved on an Ultimate XB-C8 (2.1 × 50 mm,… read more here.
Keywords: drug; human plasma; edaravone taurine; taurine ... See more keywords
A validated Ultra HPLC-MS/MS method for determination of TQ-B3203 in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumor.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of separation science"
DOI: 10.1002/jssc.202001023
Abstract: TQ-B3203 is a new topoisomerase I inhibitor derived from camptothecin. In this paper, a simple and reliable ultra high performance liquid chromatography-tandem mass spectrometric method was developed and validated for determination of TQ-B3203 in human… read more here.
Keywords: plasma; b3203 human; human plasma; determination b3203 ... See more keywords
Sensitive and Selective Bioscreening of the Most Commonly Used Coronavirus Disease Drug, Favipiravir, and Its Co-Administered therapeutic, Meropenem, in Human Plasma.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202200332
Abstract: Favipiravir and Meropenem have been concurrently used as directly acting antiviral and antibiotic agents for the treatment of coronavirus disease in human plasma. Accurate and specific reversed phase ultra-performance liquid chromatographic and high performance thin… read more here.
Keywords: human plasma; coronavirus disease; meropenem; favipiravir ... See more keywords
Development of a capillary electrophoretic method for determination of ketorolac enantiomers in human plasma using cationic β-cyclodextrin derivative as a chiral selector.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202200601
Abstract: A novel approach for separation of ketorolac enantiomers by CE is presented. Cationic β-cyclodextrin derivative based on imidazole was synthesized and used as a chiral selector in background electrolyte. The influence of pH and ionic… read more here.
Keywords: cyclodextrin derivative; human plasma; chiral selector; ketorolac ... See more keywords
Rapid Determination of Galantamine in Human Plasma by Microchip Electrophoresis With a Highly Integrated Contactless Conductivity Detector.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of separation science"
DOI: 10.1002/jssc.70013
Abstract: A novel and rapid method was developed for the determination of galantamine in human plasma by microchip electrophoresis with a highly integrated contactless conductivity detector (CCD). The instrumental parameters affecting the response of the detector,… read more here.
Keywords: human plasma; highly integrated; determination; electrophoresis ... See more keywords
Piperine Decreases Binding of Drugs to Human Plasma and Increases Uptake by Brain Microvascular Endothelial Cells
Sign Up to like & getrecommendations! Published in 2017 at "Phytotherapy Research"
DOI: 10.1002/ptr.5929
Abstract: We previously reported that piperine, an active alkaloidal principal of black and long peppers, enhances drug bioavailability by inhibiting drug metabolism. Another mechanism influencing drug availability/uptake is its free fraction. Since piperine is highly lipophilic,… read more here.
Keywords: human plasma; brain microvascular; drug; piperine ... See more keywords