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   Articles with "human platelet" as a keyword



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Potential of a novel scaffold composed of human platelet lysate and fibrin for human corneal endothelial cells.

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recommendations! Published in 2021 at "Cell and tissue banking"

DOI: 10.1007/s10561-021-09931-x

Abstract: Cell-based therapies have been emerged to find innovative solutions for corneal endothelial dysfunction. The aim of this study is to investigate the suitability of a blended scaffold containing human platelet lysate (HPL) and fibrin not… read more here.

Keywords: hpl fibrin; scaffold; corneal endothelial; fibrin ... See more keywords
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Calcium sequestration by human platelet acidic organelles is regulated by the actin cytoskeleton and autocrine 5-hydroxytryptamine.

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recommendations! Published in 2021 at "Cell calcium"

DOI: 10.1016/j.ceca.2021.102522

Abstract: Human platelets regulate agonist-evoked Ca2+ signalling through Ca2+ release from and sequestration into acidic organelles. Previous studies have pharmacologically characterised the presence of a Ca2+-H+ exchanger in these organelles. This exchanger appears to regulate a… read more here.

Keywords: acidic organelles; human platelet; ca2; cytochalasin ... See more keywords
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Characterization of a pathogen reduced human platelet lysate

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recommendations! Published in 2018 at "Cytotherapy"

DOI: 10.1016/j.jcyt.2018.02.168

Abstract: As more manufactured cellular therapies move into clinical use, there is an increasing call for cell culture media supplements that are of high quality, compatible with different cell types, and not supply-limited. Human platelet lysate… read more here.

Keywords: pathogen reduced; characterization pathogen; human platelet; platelet lysate ... See more keywords
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A highly standardized and characterized human platelet lysate for efficient and reproducible expansion of human bone marrow mesenchymal stromal cells.

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recommendations! Published in 2019 at "Cytotherapy"

DOI: 10.1016/j.jcyt.2019.04.053

Abstract: BACKGROUND Human platelet lysate (hPL) represents a powerful alternative to fetal bovine serum (FBS) for human mesenchymal stromal cell (hMSC) expansion. However, the large variability in hPL sources and production protocols gives rise to discrepancies… read more here.

Keywords: 200 dhpl; mesenchymal stromal; standardization; expansion ... See more keywords
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Gamma irradiated human platelet lysate as a serum substitute for ex vivo expansion of immune cells

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recommendations! Published in 2020 at "Cytotherapy"

DOI: 10.1016/j.jcyt.2020.03.272

Abstract: Background & Aim Adoptive immunotherapy is emerged as one of the leading treatments in cancer. The clinical applications require ex vivo expansion of lymphocytes to therapeutic doses in a timely manner under strict cGMP compliance.… read more here.

Keywords: vivo expansion; expansion; hpl; human platelet ... See more keywords
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Probing the Electrostatic and Steric Requirements for Substrate Binding in Human Platelet-Type 12-Lipoxygenase.

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recommendations! Published in 2019 at "Biochemistry"

DOI: 10.1021/acs.biochem.8b01167

Abstract: Human platelet ALOX12 (hALOX12 or h12-LOX) has been implicated in a variety of human diseases. The present study investigates the active site of hALOX12 to more thoroughly understand how it positions the substrate and achieves… read more here.

Keywords: substrate binding; probing electrostatic; active site; site ... See more keywords
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Human Platelet Vesicles Exhibit Distinct Size and Proteome.

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recommendations! Published in 2017 at "Journal of proteome research"

DOI: 10.1021/acs.jproteome.7b00309

Abstract: In the past 50 years, isolated blood platelets have had restricted use in wound healing, cancer therapy, and organ and tissue transplant, to name a few. The major obstacle for its unrestricted use has been,… read more here.

Keywords: secretory vesicles; size; human platelet; platelet ... See more keywords
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Comparison of human platelet lysate alternatives using expired and freshly isolated platelet concentrates for adipose-derived stromal cell expansion

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recommendations! Published in 2019 at "Platelets"

DOI: 10.1080/09537104.2018.1445840

Abstract: Abstract Pooled human platelet lysate (pHPL) has been used to expand adipose-derived stromal cells (ASCs) and can be formulated using fresh or expired buffy coats (BCs) which are then resuspended in either plasma or an… read more here.

Keywords: phpl alternatives; expansion; human platelet; cell ... See more keywords
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Human platelet antigen 1, 2 and 5 gene polymorphisms in Egyptians and their potential association with susceptibility to immune thrombocytopenic purpura in Egyptian patients

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recommendations! Published in 2018 at "Hematology"

DOI: 10.1080/10245332.2017.1365435

Abstract: ABSTRACT Objectives: This study determined the incidence of HPA1, HPA2 and HPA5 polymorphisms in 120 Egyptian immune thrombocytopenic purpura (ITP) patients and 120 healthy Egyptian subjects. Methods: Human platelet antigen (HPA) genotyping was done using… read more here.

Keywords: frequency; platelet antigen; immune thrombocytopenic; human platelet ... See more keywords
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Efficacy and Tolerability of Topical Platelet Exosomes for Skin Rejuvenation: Six-Week Results.

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recommendations! Published in 2022 at "Aesthetic surgery journal"

DOI: 10.1093/asj/sjac149

Abstract: BACKGROUND Exosomes are regenerative mediators for skin rejuvenation. In the context of aesthetic medicine, platelets are an ideal source for exosomal isolation given their role in skin healing. Human platelet extract (HPE) is an allogeneic… read more here.

Keywords: platelet; skin health; skin rejuvenation; human platelet ... See more keywords

A Simple and Applicable Method for Human Platelet Lysate Preparation Using Citrate Blood.

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recommendations! Published in 2022 at "Laboratory medicine"

DOI: 10.1093/labmed/lmab116

Abstract: OBJECTIVES To determine and compare the platelet growth factors in human platelet lysate (HPL) prepared from citrated whole blood, with final centrifugations at 4oC and 25oC. METHODS We collected specimens of citrated whole blood from… read more here.

Keywords: platelet lysate; citrated whole; human platelet; platelet ... See more keywords