Investigating and Resolving Cardiotoxicity Induced by COVID‐19 Treatments using Human Pluripotent Stem Cell‐Derived Cardiomyocytes and Engineered Heart Tissues
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202203388
Abstract: Coronavirus disease 2019 continues to spread worldwide. Given the urgent need for effective treatments, many clinical trials are ongoing through repurposing approved drugs. However, clinical data regarding the cardiotoxicity of these drugs are limited. Human… read more here.
Keywords: cell; stem cell; pluripotent stem; human pluripotent ... See more keywords
Symmetry Breaking of Human Pluripotent Stem Cells (hPSCs) in Micropattern Generates a Polarized Spinal Cord-Like Organoid (pSCO) with Dorsoventral Organization.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202301787
Abstract: Axis formation and related spatial patterning are initiated by symmetry breaking during development. A geometrically confined culture of human pluripotent stem cells (hPSCs) mimics symmetry breaking and cell patterning. Using this, polarized spinal cord organoids… read more here.
Keywords: pluripotent stem; human pluripotent; spinal cord; symmetry breaking ... See more keywords
Chalcone Supported Cardiac Mesoderm Induction in Human Pluripotent Stem Cells for Heart Muscle Engineering.
Sign Up to like & getrecommendations! Published in 2021 at "ChemMedChem"
DOI: 10.1002/cmdc.202100222
Abstract: Human pluripotent stem cells (hPSCs) hold great promise for applications in cell therapy and drug screening in the cardiovascular field. Bone morphogenetic protein 4 (BMP4) is key for early cardiac mesoderm induction in hPSC and… read more here.
Keywords: cardiac mesoderm; mesoderm induction; human pluripotent; pluripotent stem ... See more keywords
PEAR1 is a potential regulator of early hematopoiesis of human pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30924
Abstract: Hemogenic endothelial (HE) cells are specialized endothelial cells to give rise to hematopoietic stem/progenitor cells during hematopoietic development. The underlying mechanisms that regulate endothelial‐to‐hematopoietic transition (EHT) of human HE cells are not fully understand. Here,… read more here.
Keywords: human pluripotent; regulator early; hematopoietic development; pear1 cells ... See more keywords
Tyrosine Kinase Expressed in Hepatocellular Carcinoma, TEC, Controls Pluripotency and Early Cell Fate Decisions of Human Pluripotent Stem Cells via Regulation of Fibroblast Growth Factor‐2 Secretion
Sign Up to like & getrecommendations! Published in 2017 at "STEM CELLS"
DOI: 10.1002/stem.2660
Abstract: Human pluripotent stem cells (hPSC) require signaling provided by fibroblast growth factor (FGF) receptors. This can be initiated by the recombinant FGF2 ligand supplied exogenously, but hPSC further support their niche by secretion of endogenous… read more here.
Keywords: human pluripotent; secretion; kinase; tec ... See more keywords
Concise Review: Kidney Generation with Human Pluripotent Stem Cells
Sign Up to like & getrecommendations! Published in 2017 at "STEM CELLS"
DOI: 10.1002/stem.2699
Abstract: Chronic kidney disease (CKD) is a worldwide health care problem, resulting in increased cardiovascular mortality and often leading to end‐stage kidney disease, where patients require kidney replacement therapies such as hemodialysis or kidney transplantation. Loss… read more here.
Keywords: kidney; human pluripotent; pluripotent stem; stem cells ... See more keywords
Low Osteogenic Yield in Human Pluripotent Stem Cells Associates with Differential Neural Crest Promoter Methylation
Sign Up to like & getrecommendations! Published in 2018 at "STEM CELLS"
DOI: 10.1002/stem.2746
Abstract: Human pluripotent stem cell‐derived osteoblasts possess great potential for use in bone disorder elucidation and repair; however, while the general ability of human pluripotent stem cells to differentiate into osteoblasts and lay down bone‐specific matrix… read more here.
Keywords: human pluripotent; pluripotent stem; neural crest; stem ... See more keywords
Concise Review: Human Pluripotent Stem Cells to Produce Cell‐Based Cancer Immunotherapy
Sign Up to like & getrecommendations! Published in 2018 at "STEM CELLS"
DOI: 10.1002/stem.2754
Abstract: Human pluripotent stem cells (PSCs) provide a promising resource to produce immune cells for adoptive cellular immunotherapy to better treat and potentially cure otherwise lethal cancers. Cytotoxic T cells and natural killer (NK) cells can… read more here.
Keywords: human pluripotent; immunotherapy; pluripotent stem; stem ... See more keywords
ESRP1‐Induced CD44 v3 Is Important for Controlling Pluripotency in Human Pluripotent Stem Cells
Sign Up to like & getrecommendations! Published in 2018 at "STEM CELLS"
DOI: 10.1002/stem.2864
Abstract: The importance of alternative splicing (AS) events in pluripotency regulation has been highlighted by the determination of different roles and contributions of different splice isoforms of pluripotency‐related genes and by the identification of distinct pluripotency‐related… read more here.
Keywords: esrp1; human pluripotent; pluripotency; cd44 ... See more keywords
Accessing the Human Pluripotent Stem Cell Translatome by Polysome Profiling.
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DOI: 10.1007/7651_2021_437
Abstract: Polysome profiling is a technique that uses sucrose density gradient ultracentrifugation to separate complexes of mRNAs associated with one or more ribosomes. Here we describe polysome profiling analysis in human pluripotent stem cells (hPSCs) using… read more here.
Keywords: human pluripotent; polysome profiling; stem cell; pluripotent stem ... See more keywords
Revised "hPSC-Sac Method" for Simple and Efficient Differentiation of Human Pluripotent Stem Cells to Hematopoietic Progenitor Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/7651_2021_443
Abstract: The human hematopoietic differentiation in vitro of human pluripotent stem cells (hPSCs) has provided new tools to elucidate the mechanisms of related genetic abnormalities, such as congenital diseases and acquired hematopoietic malignancies, and to discover… read more here.
Keywords: human pluripotent; method; hpsc sac; differentiation ... See more keywords