Inflammation-driven deaminase deregulation fuels human pre-leukemia stem cell evolution.
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DOI: 10.1016/j.celrep.2020.108670
Abstract: Inflammation-dependent base deaminases promote therapeutic resistance in many malignancies. However, their roles in human pre-leukemia stem cell (pre-LSC) evolution to acute myeloid leukemia stem cells (LSCs) had not been elucidated. Comparative whole-genome and whole-transcriptome sequencing… read more here.
Keywords: evolution; human pre; stem; pre lsc ... See more keywords
An integrated chromatin accessibility and transcriptome landscape of human pre-implantation embryos
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DOI: 10.1038/s41467-018-08244-0
Abstract: Human pre-implantation embryonic development involves extensive changes in chromatin structure and transcriptional activity. Here, we report on LiCAT-seq, a technique that enables simultaneous profiling of chromatin accessibility and gene expression with ultra-low input of cells,… read more here.
Keywords: pre implantation; accessibility transcriptome; accessibility; human pre ... See more keywords