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Published in 2019 at "Archives of Toxicology"
DOI: 10.1007/s00204-019-02611-6
Abstract: Our knowledge of complex pathological mechanisms underlying organ fibrosis is predominantly derived from animal studies. However, relevance of animal models for human disease is limited; therefore, an ex vivo model of human precision-cut tissue slices…
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Keywords:
human precision;
cut tissue;
precision cut;
pathology ... See more keywords
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Published in 2022 at "Archives of toxicology"
DOI: 10.1007/s00204-022-03295-1
Abstract: Human Precision-cut intestinal slices (hPCIS) are used to study intestinal physiology, pathophysiology, drug efficacy, toxicology, kinetics, and metabolism. However, the use of this ex vivo model is restricted to approximately a 24 h timeframe because of…
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Keywords:
toxicology;
metabolism;
viability;
cultured hpcis ... See more keywords
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Published in 2023 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfac136
Abstract: Abstract Human precision-cut lung slices (hPCLS), considered a highly relevant ex vivo model of the lung, offer native architecture and cells of the lung tissue including respiratory parenchyma, small airways, and immune competent cells. However,…
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Keywords:
cut lung;
lung slices;
lung;
human precision ... See more keywords