Transcriptomic characterization of culture-associated changes in murine and human precision-cut tissue slices
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DOI: 10.1007/s00204-019-02611-6
Abstract: Our knowledge of complex pathological mechanisms underlying organ fibrosis is predominantly derived from animal studies. However, relevance of animal models for human disease is limited; therefore, an ex vivo model of human precision-cut tissue slices… read more here.
Keywords: human precision; cut tissue; precision cut; pathology ... See more keywords
Extending the viability of human precision-cut intestinal slice model for drug metabolism studies.
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DOI: 10.1007/s00204-022-03295-1
Abstract: Human Precision-cut intestinal slices (hPCIS) are used to study intestinal physiology, pathophysiology, drug efficacy, toxicology, kinetics, and metabolism. However, the use of this ex vivo model is restricted to approximately a 24 h timeframe because of… read more here.
Keywords: toxicology; metabolism; viability; cultured hpcis ... See more keywords
Cryopreserved human precision-cut lung slices provide an immune competent pulmonary test system for “on-demand” use and long-term cultures
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DOI: 10.1093/toxsci/kfac136
Abstract: Abstract Human precision-cut lung slices (hPCLS), considered a highly relevant ex vivo model of the lung, offer native architecture and cells of the lung tissue including respiratory parenchyma, small airways, and immune competent cells. However,… read more here.
Keywords: cut lung; lung slices; lung; human precision ... See more keywords