On the origins and fate of chromosomal abnormalities in human preimplantation embryos: an unsolved riddle.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular human reproduction"
DOI: 10.1093/molehr/gaac011
Abstract: About 8 out of 10 human embryos obtained in vitro harbour chromosomal abnormalities of either meiotic or mitotic origin. Abnormalities of mitotic origin lead to chromosomal mosaicism, a phenomenon which has sparked much debate lately… read more here.
Keywords: fate chromosomal; origins fate; abnormalities human; embryos ... See more keywords
5-Formylcytosine landscapes of human preimplantation embryos at single-cell resolution
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Biology"
DOI: 10.1371/journal.pbio.3000799
Abstract: Epigenetic dynamics, such as DNA methylation and chromatin accessibility, have been extensively explored in human preimplantation embryos. However, the active demethylation process during this crucial period remains largely unexplored. In this study, we use single-cell… read more here.
Keywords: single cell; preimplantation embryos; human preimplantation;
Histone remodeling reflects conserved mechanisms of bovine and human preimplantation development
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DOI: 10.15252/embr.202255726
Abstract: How histone modifications regulate changes in gene expression during preimplantation development in any species remains poorly understood. Using CUT&Tag to overcome limiting amounts of biological material, we profiled two activating (H3K4me3 and H3K27ac) and two… read more here.
Keywords: preimplantation development; preimplantation; human preimplantation; histone remodeling ... See more keywords