Irritating effects of sodium lauryl sulfate on human primary keratinocytes at subtoxic levels of exposure
Sign Up to like & getrecommendations! Published in 2018 at "Microscopy Research and Technique"
DOI: 10.1002/jemt.23143
Abstract: Chemical agents that can potentially cause skin irritation are typically tested in animal models or in vitro assays of cell viability or cytokine expression. However, these methods do not always provide translatable results and are… read more here.
Keywords: primary keratinocytes; lauryl sulfate; microscopy; sodium lauryl ... See more keywords
Combined treatment of AT101 and demethoxycurcumin yields an enhanced anti-proliferative effect in human primary glioblastoma cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-019-03107-7
Abstract: Purpose Glioblastoma multiforme (GBM) is a poorly curable disease due to its profound chemoresistance. Despite recent advances in surgery, radiotherapy and chemotherapy, the efficient treatment of GBMs is still a clinical challenge. Beside others, AT101,… read more here.
Keywords: anti proliferative; treatment; human primary; treatment at101 ... See more keywords
IGF-1-Mediated Survival from Induced Death of Human Primary Cultured Retinal Pigment Epithelial Cells Is Mediated by an Akt-Dependent Signaling Pathway
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0447-0
Abstract: Degeneration of the human retinal pigmented epithelium (hRPE) is involved in several eye disorders such as age-related macular degeneration (AMD). In this study, we investigated the protective effect of IGF-1 on human primary cultured RPE… read more here.
Keywords: akt; rpe cells; effect; igf ... See more keywords
Epigallocatechin-3-gallate exhibits immunomodulatory effects in human primary T cells.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.02.132
Abstract: T cells secrete several inflammatory cytokines that play a critical role in the progression of atherosclerosis. Although green tea epigallocatechin-3-gallate (EGCG) exerts anti-inflammatory and anti-atherosclerotic effects in animals, few studies have identified the mechanism underlying… read more here.
Keywords: gallate exhibits; human primary; epigallocatechin gallate; primary cells ... See more keywords
Type IV collagen reduces mucin 5AC secretion in three-dimensional cultured human primary airway epithelial cells
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2019.100707
Abstract: Mucin 5AC (MUC5AC) hypersecretion induces airway narrowing in patients with asthma, which leads to breathing problems. We investigated the regulation of MUC5AC secretion by extracellular matrix (ECM) proteins in human primary airway epithelial cells from… read more here.
Keywords: muc5ac secretion; secretion; primary airway; human primary ... See more keywords
Epigenetic Deregulation in Human Primary Immunodeficiencies.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in immunology"
DOI: 10.1016/j.it.2018.11.005
Abstract: Primary immunodeficiencies (PIDs) are immune disorders resulting from defects in genes involved in immune regulation, and manifesting as an increased susceptibility to infections, autoimmunity, and cancer. However, the molecular basis of some prevalent entities remains… read more here.
Keywords: epigenetic deregulation; deregulation human; primary immunodeficiencies; human primary ... See more keywords
Aryl hydrocarbon receptor (AhR) agonist β-naphthoflavone regulated gene networks in human primary trophoblasts.
Sign Up to like & getrecommendations! Published in 2020 at "Reproductive toxicology"
DOI: 10.1016/j.reprotox.2020.08.008
Abstract: The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is highly expressed in placenta. AhR belongs to a class of transcriptional regulators that control many developmental and physiological events (e.g. xenobiotic metabolism). Our… read more here.
Keywords: ahr agonist; hydrocarbon receptor; aryl hydrocarbon; human primary ... See more keywords
SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytes
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death Discovery"
DOI: 10.1038/s41420-021-00428-w
Abstract: Infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with leukopenia and uncontrolled inflammatory response in critically ill patients. A better comprehension of SARS-CoV-2-induced monocyte death is essential for the identification… read more here.
Keywords: cov engages; engages inflammasome; primary monocytes; human primary ... See more keywords
High-efficiency RNA-based reprogramming of human primary fibroblasts
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03190-3
Abstract: Induced pluripotent stem cells (iPSCs) hold great promise for regenerative medicine; however, their potential clinical application is hampered by the low efficiency of somatic cell reprogramming. Here, we show that the synergistic activity of synthetic… read more here.
Keywords: medicine; primary fibroblasts; synergistic activity; reprogramming human ... See more keywords
Organotypic culture assays for murine and human primary and metastatic-site tumors
Sign Up to like & getrecommendations! Published in 2020 at "Nature Protocols"
DOI: 10.1038/s41596-020-0335-3
Abstract: Cancer invasion and metastasis are challenging to study in vivo since they occur deep inside the body over extended time periods. Organotypic 3D culture of fresh tumor tissue enables convenient real-time imaging, genetic and microenvironmental… read more here.
Keywords: organotypic culture; primary metastatic; human primary; metastatic site ... See more keywords
Expansion of human primary hepatocytes in vitro through their amplification as liver progenitors in a 3D organoid system
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-26584-1
Abstract: Despite decades of investigation on the proliferation of adult human primary hepatocytes, their expansion in vitro still remains challenging. To later be able to consider hepatocytes as a cell therapy alternative or bridge to liver… read more here.
Keywords: expansion; primary hepatocytes; liver progenitors; human primary ... See more keywords