Bridging the gap between rodents and humans: The role of non‐human primates in oxytocin research
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Primatology"
DOI: 10.1002/ajp.22756
Abstract: Oxytocin (OT), a neuropeptide that acts in the brain as a neuromodulator, has been long known to shape maternal physiology and behavior in mammals, however its role in regulating social cognition and behavior in primates… read more here.
Keywords: gap; non human; social cognition; rodents humans ... See more keywords
Evaluation of Gadolinium‐Based Contrast Agents in Juvenile Non‐Human Primates Including Behavioral Evaluations Such as Learning and Memory
Sign Up to like & getrecommendations! Published in 2025 at "Birth Defects Research"
DOI: 10.1002/bdr2.2470
Abstract: The US Food and Drug Administration (FDA) requested the four Gadolinium‐Based Contrast Agents (GBCA) New Drug Application (NDA) holders to investigate the effects of gadolinium (Gd) retention on fetal and neonatal development in mice and… read more here.
Keywords: juvenile non; contrast agents; non human; human primates ... See more keywords
Protective Efficacy of Inactivated Vaccine against SARS-CoV-2 Infection in Mice and Non-Human Primates
Sign Up to like & getrecommendations! Published in 2021 at "Virologica Sinica"
DOI: 10.1007/s12250-021-00376-w
Abstract: The ongoing coronavirus disease 2019 (COVID-19) pandemic caused more than 96 million infections and over 2 million deaths worldwide so far. However, there is no approved vaccine available for severe acute respiratory syndrome coronavirus 2… read more here.
Keywords: inactivated vaccine; non human; efficacy; sars cov ... See more keywords
Systemic mRNA Therapy for the Treatment of Fabry Disease: Preclinical Studies in Wild-Type Mice, Fabry Mouse Model, and Wild-Type Non-human Primates.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2019.02.003
Abstract: Fabry disease is an X-linked lysosomal storage disease caused by loss of alpha galactosidase A (α-Gal A) activity and is characterized by progressive accumulation of globotriaosylceramide and its analogs in all cells and tissues. Although… read more here.
Keywords: non human; fabry disease; mice; human primates ... See more keywords
Mapping Polyclonal Antibody Responses in Non-human Primates Vaccinated with HIV Env Trimer Subunit Vaccines.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.02.061
Abstract: Rational immunogen design aims to focus antibody responses to vulnerable sites on primary antigens. Given the size of these antigens, there is, however, potential for eliciting unwanted, off-target responses. Here, we use our electron microscopy… read more here.
Keywords: non human; microscopy; antibody; human primates ... See more keywords
How do non-human primates represent others' awareness of where objects are hidden?
Sign Up to like & getrecommendations! Published in 2021 at "Cognition"
DOI: 10.1016/j.cognition.2021.104658
Abstract: Although non-human primates (NHPs) generally appear to predict how knowledgeable agents use knowledge to guide their behavior, the cognitive mechanisms that enable this remain poorly understood. We assessed the conditions under which NHPs' representations of… read more here.
Keywords: agent; color; non human; experiment ... See more keywords
Non-human primates and Leishmania immunity
Sign Up to like & getrecommendations! Published in 2020 at "Cytokine"
DOI: 10.1016/j.cytox.2020.100038
Abstract: In the context of infectious diseases, non-human primates (NHP) provide the best animal models of human diseases due to the close phylogenetic relationship and the similar physiology and anatomical systems. Herein, we summarized the contribution… read more here.
Keywords: leishmania immunity; non human; primates leishmania; physiology ... See more keywords
An autonomous, automated and mobile device to concurrently assess several cognitive functions in group-living non-human primates
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2017.07.013
Abstract: HighlightsWe present a tool to concurrently assess several cognitive functions in primates.This experimental system combines automatization and mobility.This system allows testing cognitive performance in group‐living subjects.Using this device, macaques learned several cognitive tasks rapidly.Macaques showed… read more here.
Keywords: non human; group living; several cognitive; concurrently assess ... See more keywords
Do Non-Human Primates Really Represent Others’ Beliefs?
Sign Up to like & getrecommendations! Published in 2020 at "Trends in Cognitive Sciences"
DOI: 10.1016/j.tics.2020.05.009
Abstract: Over two decades of research have produced compelling evidence that non-human primates understand some psychological states in other individuals but are unable to represent others' beliefs. Recently, three studies employing anticipatory looking (AL) paradigms reported… read more here.
Keywords: non human; primates really; others beliefs; really represent ... See more keywords
Exploratory EEG studies for the assessment of neurological liabilities in conscious dogs in early drug development.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmacological and toxicological methods"
DOI: 10.1016/j.vascn.2019.106581
Abstract: INTRODUCTION Convulsions in toxicology studies can be the first indication of seizure liability. Drug levels during convulsions are not usually evaluated. This, and exposure variability after oral administration, complicates estimation of safety margins. The electroencephalogram… read more here.
Keywords: neurological symptoms; non human; drug; human primates ... See more keywords
AAV9-mediated engineering of autotransplanted kidney of non-human primates
Sign Up to like & getrecommendations! Published in 2017 at "Gene Therapy"
DOI: 10.1038/gt.2017.21
Abstract: Ex vivo gene transfer to the graft before transplantation is an attractive option for circumventing systemic side effects of chronic antirejection therapy. Gene delivery of the immunomodulatory protein cytotoxic T-lymphocyte-associated protein 4–immunoglobulin (CTLA4-Ig) prevented chronic… read more here.
Keywords: non human; kidney non; mediated engineering; human primates ... See more keywords