Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation
Sign Up to like & getrecommendations! Published in 2020 at "Nature cell biology"
DOI: 10.1038/s41556-020-00607-4
Abstract: X-chromosome dosage compensation in female placental mammals is achieved by X-chromosome inactivation (XCI). An exception are human pre-implantation embryos, where dosage compensation occurs by X-chromosome dampening (XCD). Here, we examined whether XCD extends to human… read more here.
Keywords: dosage compensation; germ cells; dosage; chromosome dosage ... See more keywords
DAZL regulates proliferation of human primordial germ cells by direct binding to precursor miRNAs and enhances DICER processing activity
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac856
Abstract: Abstract Understanding the molecular and cellular mechanisms of human primordial germ cells (hPGCs) is essential in studying infertility and germ cell tumorigenesis. Many RNA-binding proteins (RBPs) and non-coding RNAs are specifically expressed and functional during… read more here.
Keywords: cell; germ; proliferation; human primordial ... See more keywords