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   Articles with "human primpol" as a keyword



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Significant impact of divalent metal ions on the fidelity, sugar selectivity, and drug incorporation efficiency of human PrimPol.

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recommendations! Published in 2017 at "DNA repair"

DOI: 10.1016/j.dnarep.2016.11.003

Abstract: Human PrimPol is a recently discovered bifunctional enzyme that displays DNA template-directed primase and polymerase activities. PrimPol has been implicated in nuclear and mitochondrial DNA replication fork progression and restart as well as DNA lesion… read more here.

Keywords: mn2; primpol; human primpol; sugar selectivity ... See more keywords
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Translesion Synthesis across the N2-Ethyl-deoxyguanosine Adduct by Human PrimPol.

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recommendations! Published in 2022 at "ACS chemical biology"

DOI: 10.1021/acschembio.2c00717

Abstract: Primase-DNA polymerase (PrimPol) is involved in reinitiating DNA synthesis at stalled replication forks. PrimPol also possesses DNA translesion (TLS) activity and bypasses several endogenous nonbulky DNA lesions in vitro. Little is known about the TLS… read more here.

Keywords: dna; primpol; translesion; synthesis ... See more keywords
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Human PrimPol activity is enhanced by RPA

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-00958-3

Abstract: Human PrimPol is a primase belonging to the AEP superfamily with the unique ability to synthesize DNA primers de novo, and a non-processive DNA polymerase able to bypass certain DNA lesions. PrimPol facilitates both mitochondrial… read more here.

Keywords: primpol activity; primpol; ssdna; human primpol ... See more keywords
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Engineering human PrimPol into an efficient RNA-dependent-DNA primase/polymerase

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recommendations! Published in 2017 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkx633

Abstract: Abstract We have developed a straightforward fluorometric assay to measure primase-polymerase activity of human PrimPol (HsPrimPol). The sensitivity of this procedure uncovered a novel RNA-dependent DNA priming-polymerization activity (RdDP) of this enzyme. In an attempt… read more here.

Keywords: rna dependent; dna; human primpol; primase polymerase ... See more keywords