Human Prion Disease Surveillance in Washington State, 2006-2017
Sign Up to like & getrecommendations! Published in 2020 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2020.20690
Abstract: Key Points Question What are the results of human prion disease surveillance in Washington state? Findings In this cross-sectional study using state surveillance data from 2006 to 2017, 143 human prion disease cases were detected,… read more here.
Keywords: state; surveillance; prion; disease ... See more keywords
1H, 13C, 15N backbone and side-chain resonance assignments of the pathogenic G131V mutant of human prion protein (91-231).
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecular NMR assignments"
DOI: 10.1007/s12104-021-10022-x
Abstract: Human prion disease, also known as transmissible spongiform encephalopathy (TSEs), is caused by the conformational conversion of the normal cellular prion protein (PrPC) into the scrapie form (PrPSc). Pathogenic point mutations of prion proteins typically… read more here.
Keywords: prion; human prion; prion protein; backbone ... See more keywords
Recognition Mechanisms between a Nanobody and Disordered Epitopes of the Human Prion Protein: An Integrative Molecular Dynamics Study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.2c01062
Abstract: Immunotherapy using antibodies to target the aggregation of flexible proteins holds promise for therapeutic interventions in neurodegenerative diseases caused by protein misfolding. Prions or PrPSc, the causal agents of transmissible spongiform encephalopathies (TSE), represent a… read more here.
Keywords: recognition; human prion; recognition mechanisms; disordered epitopes ... See more keywords
Artificial strain of human prions created in vitro
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04584-z
Abstract: The molecular mechanism that determines under physiological conditions transmissibility of the most common human prion disease, sporadic Creutzfeldt-Jakob disease (sCJD) is unknown. We report the synthesis of new human prion from the recombinant human prion… read more here.
Keywords: prion; prion protein; human prions; strain ... See more keywords
Differential overexpression of SERPINA3 in human prion diseases
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-15778-8
Abstract: Prion diseases are fatal neurodegenerative disorders with sporadic, genetic or acquired etiologies. The molecular alterations leading to the onset and the spreading of these diseases are still unknown. In a previous work we identified a… read more here.
Keywords: prion; overexpression serpina3; prion diseases; differential overexpression ... See more keywords
Structural effects of the highly protective V127 polymorphism on human prion protein
Sign Up to like & getrecommendations! Published in 2020 at "Communications Biology"
DOI: 10.1038/s42003-020-01126-6
Abstract: Prion diseases, a group of incurable, lethal neurodegenerative disorders of mammals including humans, are caused by prions, assemblies of misfolded host prion protein (PrP). A single point mutation (G127V) in human PrP prevents prion disease,… read more here.
Keywords: prion; human prion; prion disease; prion protein ... See more keywords
Simulation analysis of selective alanine mutation effect on stability of human prion protein
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2022.2036237
Abstract: Abstract Prion diseases are neurodegenerative disorders caused by spongiform degeneration of the brain. Understanding the fundamental mechanism of prion protein aggregation caused by mutations is very crucial to resolve the pathology of prion diseases. To… read more here.
Keywords: prion; prion protein; stability human; human prion ... See more keywords
Frequent Detection of Pituitary-Derived PrPres in Human Prion Diseases.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlz075
Abstract: Human prion diseases including sporadic Creutzfeldt-Jakob disease (sCJD), inherited prion diseases, and acquired human prion diseases are lethal neurodegenerative diseases. One of the major sources of iatrogenic Creutzfeldt-Jakob disease was human growth hormone (hGH-iCJD) derived… read more here.
Keywords: prion; disease; prion protein; prion diseases ... See more keywords
Glial alterations in human prion diseases
Sign Up to like & getrecommendations! Published in 2018 at "Medicine"
DOI: 10.1097/md.0000000000010320
Abstract: Background: Neuroinflammation has recently been proposed to be a major component of neurodegenerative diseases. The aim of this study was to determine how the interaction between microglia and astroglia, which are the primary immune cell… read more here.
Keywords: glial alterations; alterations human; prion; disease ... See more keywords
In silico Characterization of Human Prion-Like Proteins: Beyond Neurological Diseases
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2019.00314
Abstract: Prion-like behavior has been in the spotlight since it was first associated with the onset of mammalian neurodegenerative diseases. However, a growing body of evidence suggests that this mechanism could be behind the regulation of… read more here.
Keywords: like proteins; silico characterization; prion like; prion ... See more keywords