Human protein mutagens found via bacteria
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Genetics"
DOI: 10.1038/s41576-019-0096-4
Abstract: A new study published in Cell uses bacterial genetic screens to identify mutagenic proteins. Overexpression of homologues of these proteins in human cells has similar mutagenic effects and potential prognostic value in cancer. read more here.
Keywords: mutagens found; found via; via bacteria; human protein ... See more keywords
Analysis of the Human Protein Atlas Image Classification competition
Sign Up to like & getrecommendations! Published in 2019 at "Nature Methods"
DOI: 10.1038/s41592-019-0658-6
Abstract: Pinpointing subcellular protein localizations from microscopy images is easy to the trained eye, but challenging to automate. Based on the Human Protein Atlas image collection, we held a competition to identify deep learning solutions to… read more here.
Keywords: protein; classification; protein atlas; human protein ... See more keywords
Top-ranked expressed gene transcripts of human protein-coding genes investigated with GTEx dataset
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-73081-5
Abstract: With considerable accumulation of RNA-Seq transcriptome data, we have extended our understanding about protein-coding gene transcript compositions. However, alternatively compounded patterns of human protein-coding gene transcripts would complicate gene expression data processing and interpretation. It… read more here.
Keywords: human protein; protein coding; top ranked; coding genes ... See more keywords
Reconstruction of human protein-coding gene functional association network based on machine learning
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbab552
Abstract: Networks consisting of molecular interactions are intrinsically dynamical systems of an organism. These interactions curated in molecular interaction databases are still not complete and contain false positives introduced by high-throughput screening experiments. In this study,… read more here.
Keywords: network; coding gene; human protein; protein coding ... See more keywords
The human G protein‐coupled ATP receptor P2Y11 is a target for anti‐inflammatory strategies
Sign Up to like & getrecommendations! Published in 2021 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15379
Abstract: The ATP receptor P2Y11, which couples to Gq and Gs proteins, senses cell stress and promotes cytoprotective responses. P2Y11 receptors are upregulated during differentiation of M2 macrophages. However, it is unclear whether and how P2Y11… read more here.
Keywords: anti inflammatory; receptor p2y11; human protein; p2y11 ... See more keywords
Understanding Human-Virus Protein-Protein Interactions Using a Human Protein Complex-Based Analysis Framework
Sign Up to like & getrecommendations! Published in 2019 at "mSystems"
DOI: 10.1128/msystems.00303-18
Abstract: Although human protein complexes have been reported to be directly related to viral infection, previous studies have not systematically investigated human-virus PPIs from the perspective of human protein complexes. To the best of our knowledge,… read more here.
Keywords: protein complexes; human virus; virus; human protein ... See more keywords
Recombinant Analogue of the Human Protein SLURP-1 Inhibits the Growth of U251 MG and A172 Glioma Cells
Sign Up to like & getrecommendations! Published in 2020 at "Doklady Biochemistry and Biophysics"
DOI: 10.1134/s1607672920040134
Abstract: Abstract The alpha7 nicotinic acetylcholine receptor (α7-nAChR) is considered a promising pharmacological target for the carcinoma therapy. We have previously shown that the recombinant analogue of the human protein SLURP-1 (rSLURP-1) effectively inhibits the growth… read more here.
Keywords: recombinant analogue; human protein; u251 a172; analogue human ... See more keywords
Blocking human protein C anticoagulant activity improves clotting defects of hemophilia mice expressing human protein C
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2021006214
Abstract: Key Points We generated novel hemophilia A or B mice expressing human protein C. Selectively blocking the anticoagulant activity of human activated protein C improves the clotting defects in hemophilia mice. read more here.
Keywords: human protein; mice expressing; expressing human; anticoagulant activity ... See more keywords
A multitask transfer learning framework for the prediction of virus-human protein–protein interactions
Sign Up to like & getrecommendations! Published in 2021 at "BMC Bioinformatics"
DOI: 10.1186/s12859-021-04484-y
Abstract: Background Viral infections are causing significant morbidity and mortality worldwide. Understanding the interaction patterns between a particular virus and human proteins plays a crucial role in unveiling the underlying mechanism of viral infection and pathogenesis.… read more here.
Keywords: virus human; protein interactions; protein protein; human protein ... See more keywords
ITC-derived binding affinity may be biased due to titrant (nano)-aggregation. Binding of halogenated benzotriazoles to the catalytic domain of human protein kinase CK2
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0173260
Abstract: The binding of four bromobenzotriazoles to the catalytic subunit of human protein kinase CK2 was assessed by two complementary methods: Microscale Thermophoresis (MST) and Isothermal Titration Calorimetry (ITC). New algorithm proposed for the global analysis… read more here.
Keywords: protein; may biased; itc derived; human protein ... See more keywords
Exploring the Role of Endoplasmic Reticulum Stress in Hepatocellular Carcinoma through mining of the Human Protein Atlas
Sign Up to like & getrecommendations! Published in 2021 at "Biology"
DOI: 10.3390/biology10070640
Abstract: Simple Summary Hepatocellular carcinoma is a highly deadly primary liver cancer. It is usually diagnosed at a late stage, when therapeutic options are scarce, and the lack of predictive biomarkers poses a challenge for early… read more here.
Keywords: hepatocellular carcinoma; endoplasmic reticulum; human protein; stress ... See more keywords