Machine learning techniques for sequence-based prediction of viral–host interactions between SARS-CoV-2 and human proteins
Sign Up to like & getrecommendations! Published in 2020 at "Biomedical Journal"
DOI: 10.1016/j.bj.2020.08.003
Abstract: Background COVID-19 (Coronavirus Disease-19), a disease caused by the SARS-CoV-2 virus, has been declared as a pandemic by the World Health Organization on March 11, 2020. Over 15 million people have already been affected worldwide… read more here.
Keywords: sars cov; human proteins; machine learning; sequence based ... See more keywords
Predicted structural mimicry of spike receptor-binding motifs from highly pathogenic human coronaviruses
Sign Up to like & getrecommendations! Published in 2021 at "Computational and Structural Biotechnology Journal"
DOI: 10.1016/j.csbj.2021.06.041
Abstract: Viruses often encode proteins that mimic host proteins in order to facilitate infection. Little work has been done to understand the potential mimicry of the SARS-CoV-2, SARS-CoV, and MERS-CoV spike proteins, particularly the receptor-binding motifs,… read more here.
Keywords: binding motifs; mimicry; spike; human proteins ... See more keywords
SARS-CoV-2-human protein-protein interaction network
Sign Up to like & getrecommendations! Published in 2020 at "Informatics in Medicine Unlocked"
DOI: 10.1016/j.imu.2020.100413
Abstract: Abstract SARS-CoV-2 is the novel coronavirus which caused the COVID-19 pandemic and infected more than 10 million victims and resulted in over 500,000 deaths in 213 countries around the world. Having no symptoms in the… read more here.
Keywords: protein; network; cov human; protein protein ... See more keywords
CarSite: identifying carbonylated sites of human proteins based on a one-sided selection resampling method.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular bioSystems"
DOI: 10.1039/c7mb00363c
Abstract: Protein carbonylation is one of the most important biomarkers of oxidative protein damage and such protein damage is linked to various diseases and aging. It is thus vital that carbonylation sites are identified accurately. In… read more here.
Keywords: one sided; sided selection; sites human; carbonylation ... See more keywords
Minimal immune determinants connect Zika virus, human Cytomegalovirus, and Toxoplasma gondii to microcephaly‐related human proteins
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Reproductive Immunology"
DOI: 10.1111/aji.12608
Abstract: Aiming at the molecular definition of the relationship(s) between prenatal infections and fetal microcephaly and using pentapeptides as minimal immune determinants, we analyzed the peptide matching between proteins from infectious agents involved in microcephalic syndromes… read more here.
Keywords: microcephaly; immune determinants; minimal immune; zika virus ... See more keywords
Disease association and comparative genomics of compositional bias in human proteins.
Sign Up to like & getrecommendations! Published in 2023 at "F1000Research"
DOI: 10.12688/f1000research.129929.2
Abstract: Background: The evolutionary rate of disordered protein regions varies greatly due to the lack of structural constraints. So far, few studies have investigated the presence/absence patterns of compositional bias, indicative of disorder, across phylogenies in… read more here.
Keywords: human proteins; disease; disease association; compositional bias ... See more keywords
Editorial: Characterizing the uncharacterized human proteins
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.1203691
Abstract: As of the first week of April 2023, according to the data from the UniProt Knowledgebase (https://www.uniprot.org) (UniProt Consortium, 2023), the human proteome has a record of 20,422 canonical as well as 21,998 non-canonical protein… read more here.
Keywords: human proteins; uncharacterized human; characterizing uncharacterized; canonical isoforms ... See more keywords
Cross-Reactivity as a Mechanism Linking Infections to Stroke
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2019.00469
Abstract: The relevance of infections as risk factor for cerebrovascular disease is being increasingly recognized. Nonetheless, the pathogenic link between the two entities remains poorly understood. Consistent with recent advances in medicine, the present work addresses… read more here.
Keywords: cross reactivity; reactivity mechanism; human proteins; mechanism linking ... See more keywords