An in vitro cytotoxicities comparison of 16 priority polycyclic aromatic hydrocarbons in human pulmonary alveolar epithelial cells HPAEpiC.
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2018.03.005
Abstract: In present study, we compared for the first time the cytotoxicities of the 16 priority polycyclic aromatic hydrocarbons (PAHs) in human pulmonary alveolar epithelial cells HPAEpiC. Moreover, we examined the effects of each PAH on… read more here.
Keywords: pulmonary alveolar; priority polycyclic; aromatic hydrocarbons; human pulmonary ... See more keywords
Tracing micro and nanoplastics toxicity in human pulmonary fibroblasts through integrated Raman and transcriptomic analyses
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DOI: 10.1038/s41598-025-22947-7
Abstract: Inhaled micro- and nanoplastics can reach the distal regions of the lungs, where their elimination is limited due to the lack of efficient clearance mechanisms. Although polystyrene particles have been detected in human lung tissue,… read more here.
Keywords: micro nanoplastics; internalization; pulmonary fibroblasts; human pulmonary ... See more keywords
Human pulmonary artery smooth muscle cell dysfunction is regulated by miR-509-5p in hypoxic environment
Sign Up to like & getrecommendations! Published in 2022 at "Cell Cycle"
DOI: 10.1080/15384101.2022.2044147
Abstract: ABSTRACT Reportedly, dysfunction of human pulmonary arterial smooth muscle cells (PASMCs) is associated with the pathogenesis of pulmonary arterial hypertension (PAH). Herein, the role of miR-509-5p in hypoxia-induced PASMCs and the underlying mechanism were explored.… read more here.
Keywords: regulated mir; human pulmonary; mir 509; dnmt1 ... See more keywords
Rutaecarpine Suppresses Proliferation and Promotes Apoptosis of Human Pulmonary Artery Smooth Muscle Cells in Hypoxia Possibly Through HIF-1α-Dependent Pathways.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000000571
Abstract: PURPOSE The aim of this study is to investigate the potential roles of Rutaecarpine (Rut) in hypoxia-induced human pulmonary artery smooth muscle cells (HPASMCs) model. METHODS HPASMCs were cultured with or without hypoxia followed by… read more here.
Keywords: proliferation; muscle cells; smooth muscle; artery smooth ... See more keywords
Vasodilatory effects of cannabidiol in human pulmonary and rat small mesenteric arteries: modification by hypertension and the potential pharmacological opportunities
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Hypertension"
DOI: 10.1097/hjh.0000000000002333
Abstract: Objective: Cannabidiol (CBD) has been suggested as a potential antihypertensive drug. The aim of our study was to investigate its vasodilatory effect in isolated human pulmonary arteries (hPAs) and rat small mesenteric arteries (sMAs). Methods:… read more here.
Keywords: rat small; human pulmonary; hypertension; mesenteric arteries ... See more keywords
10 Am2/imd secretion from human pulmonary smooth muscle cells and pulmonary fibroblasts is augmented in response to mechanical stretch
Sign Up to like & getrecommendations! Published in 2018 at "Heart"
DOI: 10.1136/heartjnl-2018-scf.20
Abstract: Introduction Pulmonary hypertension (PHT) is a severe life-limiting condition resulting in progressive shortness of breath, exercise intolerance and heart failure. PHT is defined by increased mean pulmonary arterial pressure (PAP) ≥25 mmHg at rest, and has… read more here.
Keywords: secretion; stretch; pulmonary fibroblasts; am2 imd ... See more keywords
Spike Protein Subunits of SARS-CoV-2 Alter Mitochondrial Metabolism in Human Pulmonary Microvascular Endothelial Cells: Involvement of Factor Xa
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DOI: 10.1155/2022/1118195
Abstract: Background Mitochondria have been involved in host defense upon viral infections. Factor Xa (FXa), a coagulating factor, may also have influence on mitochondrial functionalities. The aim was to analyze if in human pulmonary microvascular endothelial… read more here.
Keywords: metabolism; human pulmonary; spike; factor ... See more keywords
Caffeine, MitoQ, and GABA Prophylaxis of Mitochondrial Dysfunction Induced in Human Pulmonary Cells by Normobaric–Hyperoxia and Hyperbaric–Hyperoxia
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DOI: 10.1155/omcl/5589475
Abstract: Exposure to hyperoxia lasting either a few days at normobaria or a few hours at hyperbaria induces pulmonary oxygen toxicity. Cellular functional changes resulting from oxygen toxicity include alterations in both mitochondrial dynamics and bioenergetics.… read more here.
Keywords: respiration; gaba; human pulmonary; hyperoxia ... See more keywords
TRPV4 Stimulation Releases ATP via Pannexin Channels in Human Pulmonary Fibroblasts
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Respiratory Cell and Molecular Biology"
DOI: 10.1165/rcmb.2017-0413oc
Abstract: &NA; We previously described several ionic conductances in human pulmonary fibroblasts, including one activated by two structurally distinct TRPV4 (transient receptor potential, vanilloid‐type, subtype 4)‐channel agonists: 4&agr;PDD (4&agr;‐phorbol‐12,13‐didecanoate) and GSK1016790A. However, the TRPV4‐activated current exhibited… read more here.
Keywords: pannexin channels; pulmonary fibroblasts; atp via; human pulmonary ... See more keywords
Adjuvanting influenza hemagglutinin vaccine with a human pulmonary surfactant-mimicking synthetic compound SF-10 induces local and systemic cell-mediated immunity in mice
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DOI: 10.1371/journal.pone.0191133
Abstract: We reported previously that intranasal instillation of a synthetic human pulmonary surfactant with a carboxy vinyl polymer as a viscosity improver, named SF-10, shows potent adjuvanticity for humoral immunity in mice and cynomolgus monkeys. SF-10… read more here.
Keywords: immunity; cell mediated; pulmonary surfactant; antigen ... See more keywords
Mechanism of anti-remodelling action of treprostinil in human pulmonary arterial smooth muscle cells
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DOI: 10.1371/journal.pone.0205195
Abstract: Treprostinil is applied for pulmonary arterial hypertension (PAH) therapy. However, the mechanism by which the drug achieves its beneficial effects in PAH vessels is not fully understood. This study investigated the effects of treprostinil on… read more here.
Keywords: arterial smooth; pulmonary arterial; muscle cells; smooth muscle ... See more keywords