Discovery of a Novel Inhibitor of Human Purine Nucleoside Phosphorylase by a Simple Hydrophilic Interaction Liquid Chromatography Enzymatic Assay
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DOI: 10.1002/cmdc.202000874
Abstract: Human purine nucleoside phosphorylase (HsPNP) belongs to the purine salvage pathway of nucleic acids. Genetic deficiency of this enzyme triggers apoptosis of activated T‐cells due to the accumulation of deoxyguanosine triphosphate (dGTP). Therefore, potential chemotherapeutic… read more here.
Keywords: purine nucleoside; human purine; discovery novel; interaction ... See more keywords
Origin of Enzymatic Kinetic Isotope Effects in Human Purine Nucleoside Phosphorylase
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DOI: 10.1021/acscatal.7b04199
Abstract: Here we report a study of the effect of heavy isotope labeling on the reaction catalyzed by human purine nucleoside phosphorylase (hPNP) to elucidate the origin of its catalytic effect and of the enzymatic kinetic… read more here.
Keywords: purine nucleoside; human purine; isotope; enzymatic kinetic ... See more keywords