Human and rat renal proximal tubule in vitro models for ADME applications
Sign Up to like & getrecommendations! Published in 2025 at "Archives of Toxicology"
DOI: 10.1007/s00204-025-03987-4
Abstract: The kidney is a major organ dictating excretion rates of chemicals and their metabolites from the body and thus renal clearance is frequently a major component of pharmaco-(toxico)-kinetic profiles. Within the nephron, the proximal tubule… read more here.
Keywords: rat renal; culture; human rat; tubule ... See more keywords
Arsenite interrupts neurodevelopmental processes of human and rat neural progenitor cells: The role of reactive oxygen species and species-specific antioxidative defense.
Sign Up to like & getrecommendations! Published in 2019 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2019.06.123
Abstract: Arsenic exposure disturbs brain development in humans. Although developmental neurotoxicity (DNT) of arsenic has been studied in vivo and in vitro, its mode-of-action (MoA) is not completely understood. Here, we characterize the adverse neurodevelopmental effects of sodium… read more here.
Keywords: gsh; species specific; antioxidative defense; human rat ... See more keywords
The protective effects of silybin on the cytotoxicity of thiram in human, rat and chicken cell cultures.
Sign Up to like & getrecommendations! Published in 2017 at "Pesticide biochemistry and physiology"
DOI: 10.1016/j.pestbp.2017.08.003
Abstract: The study objective was a determination of thiram cytotoxicity and silybin cytoprotective activity in course of the fungicide impact on cell metabolism and membrane integrity. Firstly, human, rat, chicken hepatoma cells and rat myoblasts cultures… read more here.
Keywords: thiram; cell cultures; cytotoxicity; human rat ... See more keywords
Evaluation of the inhibition effects of apatinib on human and rat cytochrome P450.
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2018.08.010
Abstract: Apatinib, a small molecule anti-angiogenic drug, is proven to be safe and effective for treatment of advanced gastric cancer (AGC). It is also a single drug that significantly prolongs survival after failure of standard chemotherapy… read more here.
Keywords: apatinib human; inhibition effects; inhibition; effects apatinib ... See more keywords
Evaluation of the inhibition risk of shikonin on human and rat UDP-glucuronosyltransferases (UGT) through the cocktail approach.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2019.05.017
Abstract: Shikonin, a natural red colorant, is widely used for food garnishment and cosmetic ingredient in the world. Shikonin also possesses a variety of pharmacological actions, including anti-inflammation and anti-cancer activities. However, little is known about… read more here.
Keywords: glucuronosyltransferases ugt; udp glucuronosyltransferases; cocktail approach; shikonin ... See more keywords
Identification of Major Esterase Involved in Hydrolysis of Soft Anticholinergic (2R3'R-SGM) Designed From Glycopyrrolate in Human and Rat Tissues.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2019.03.030
Abstract: The glycopyrrolate soft analog, SGM, designed to be easily hydrolyzed into the significantly less active zwitterionic metabolite, SGa, typifies soft drug that reduces systemic side effects (a problem often seen with traditional anticholinergics) following local… read more here.
Keywords: sgm; 2r3 sgm; hydrolysis; human rat ... See more keywords
Isothiazole Disinfectants Inhibit Neurosteroid Production by Targeting Human and Rat 5α-Reductase Type 1.
Sign Up to like & getrecommendations! Published in 2025 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.5c00063
Abstract: Isothiazole disinfectants are widely used antimicrobial preservatives found in various consumer products, raising concerns about their potential effects on human health. This study investigated the inhibitory effects of seven isothiazole disinfectants on human and rat… read more here.
Keywords: human rat; reductase type; production; isothiazole disinfectants ... See more keywords
Oxyresveratrol and Gnetol Glucuronide Metabolites: Chemical Production, Structural Identification, Metabolism by Human and Rat Liver Fractions, and In Vitro Anti-inflammatory Properties
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Agricultural and Food Chemistry"
DOI: 10.1021/acs.jafc.1c07831
Abstract: Stilbene metabolites are attracting great interest because many of them exhibit similar or even stronger biological effects than their parent compounds. Furthermore, the metabolized forms are predominant in biological fluids; therefore, their study is highly… read more here.
Keywords: human rat; glucuronide metabolites; orv glucuronide; production ... See more keywords
Determining Structural Changes for Ligand Recognition between Human and Rat Phosphorylated BACE1 in Silico and Its Phosphorylation by GSK3β at Thr252 by in Vitro Studies.
Sign Up to like & getrecommendations! Published in 2024 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.3c00669
Abstract: Alzheimer's disease (AD) is a neurodegenerative disease affecting older adults. AD pathogenesis involves the production of the highly neurotoxic amyloid-β peptide 1-42 (Aβ1-42) from β-site amyloid precursor protein cleaving enzyme 1 (BACE1). The phosphorylation of… read more here.
Keywords: thr252; rat bace1; phosphorylation; human rat ... See more keywords
(−)-Epigallocatechin-3-gallate Inhibits Human and Rat Renal Organic Anion Transporters
Sign Up to like & getrecommendations! Published in 2021 at "ACS Omega"
DOI: 10.1021/acsomega.0c05586
Abstract: Organic anion transporter 1 (OAT1, SLC22A6) and 3 (OAT3, SLC22A8) are multispecific drug transporters highly expressed on the basolateral membranes of the renal proximal tubules. OAT1 and OAT3 mediate the tubular secretion of clinically significant… read more here.
Keywords: oat1 oat3; epigallocatechin gallate; organic anion; inhibits human ... See more keywords
A review of phthalate pharmacokinetics in human and rat: what factors drive phthalate distribution and partitioning?
Sign Up to like & getrecommendations! Published in 2019 at "Drug Metabolism Reviews"
DOI: 10.1080/03602532.2019.1620762
Abstract: Abstract Phthalates are a class of compounds that have been extensively used as plasticizers in different applications. Several phthalates have been recognized as substances of very high concern (SVHCs) in the EU, because of their… read more here.
Keywords: phthalate; metabolism; phthalate distribution; human rat ... See more keywords