Mechanistic characterization of S 38093, a novel inverse agonist at histamine H3 receptors
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DOI: 10.1016/j.ejphar.2017.03.013
Abstract: Abstract Histaminergic H3 inverse agonists, by stimulating central histamine release, represent attractive drug candidates to treat cognitive disorders. The present studies aimed to describe the mechanistic profile of S 38093 a novel H3 receptors inverse… read more here.
Keywords: inverse agonist; human receptors; novel inverse; agonist ... See more keywords
Structure of an LGR dimer, an evolutionary predecessor of glycoprotein hormone receptors.
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DOI: 10.1038/s41467-025-66676-x
Abstract: Glycoprotein hormones (GpHs) produced in the human pituitary act through receptors (GpHRs) in the gonads to support reproduction and in the thyroid for metabolism. GpHs are heterodimeric cystine-knot proteins; their receptors bind cognate hormones at… read more here.
Keywords: hormone; structure lgr; glycoprotein; lgr dimer ... See more keywords
Pharmacokinetics and pre-clinical efficacy of ralinepag (APD811) in humans and rats
Sign Up to like & getrecommendations! Published in 2017 at "European Respiratory Journal"
DOI: 10.1183/1393003.congress-2017.oa4662
Abstract: Background: Ralinepag is a novel, next-generation, oral, selective and potent prostacyclin (IP) receptor agonist for pulmonary arterial hypertension (PAH). Aims and objectives: Investigate affinity, potency and selectivity of ralinepag for human IP receptors vs selexipag… read more here.
Keywords: potency; human receptors; efficacy; model ... See more keywords