Obesity and Roux-en-Y gastric bypass drive changes in miR-31 and miR-215 expression in the human rectal mucosa
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DOI: 10.1038/s41366-021-01005-y
Abstract: Obesity increases colorectal cancer (CRC) risk. However, the effects of weight loss on CRC risk are unclear. Epigenetic mechanisms involving microRNAs that lead to dysregulated gene expression may mediate the effects of obesity and weight… read more here.
Keywords: rectal mucosa; weight loss; expression human; expression ... See more keywords
YAP Inhibits the Apoptosis and Migration of Human Rectal Cancer Cells via Suppression of JNK-Drp1-Mitochondrial Fission-HtrA2/Omi Pathways
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DOI: 10.1159/000485946
Abstract: Background/Aims: The Hippo-Yap pathway is associated with tumor development and progression. However, little evidence is available concerning its role in cancer cell apoptosis and migration via mitochondrial homeostasis. Here, we identify mitochondrial fission as a… read more here.
Keywords: htra2 omi; human rectal; rectal cancer; mitochondrial fission ... See more keywords
Identification of genes inducing resistance to ionizing radiation in human rectal cancer cell lines: re-sensitization of radio-resistant rectal cancer cells through down regulating NDRG1
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DOI: 10.1186/s12885-018-4514-3
Abstract: BackgroundResistance to preoperative radiotherapy is a major clinical problem in the treatment for locally advanced rectal cancer. The role of NDRG1 in resistance to ionizing radiation in rectal cancer has not been fully elucidated. This… read more here.
Keywords: rectal cancer; cell lines; cancer cells; cancer cell ... See more keywords