Use of early phenotypic in vivo markers to assess human relevance of an unusual rodent non-genotoxic carcinogen in vitro.
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology"
DOI: 10.1016/j.tox.2017.01.018
Abstract: Foci of altered hepatocytes (FAH) are considered putative, pre-neoplastic lesions that can occur spontaneously in aging rodents, but can also be induced by chemicals or drugs. Progression of FAH to hepatocellular neoplasms has been reported… read more here.
Keywords: genotoxic carcinogen; relevance; non genotoxic; human relevance ... See more keywords
Case examples of an evaluation of the human relevance of the pyrethroids/pyrethrins-induced liver tumours in rodents based on the mode of action.
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology research"
DOI: 10.1039/c7tx00288b
Abstract: Rodent carcinogenicity studies are useful for screening for human carcinogens but they are not perfect. Some modes of action (MOAs) lead to cancers in both experimental rodents and humans, but others that lead to cancers… read more here.
Keywords: relevance; human relevance; liver; tumours rodents ... See more keywords