Identification of a novel lncRNA induced by the nephrotoxin ochratoxin A and expressed in human renal tumor tissue
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-017-2731-6
Abstract: Long non-coding RNAs represent a fraction of the transcriptome that is being increasingly recognized. For most of them no function has been allocated so far. Here, we describe the nature and function of a novel… read more here.
Keywords: human renal; nephrotoxin ochratoxin; tissue; novel lncrna ... See more keywords
DNA induction of MDM2 promotes proliferation of human renal mesangial cells and alters peripheral B cells subsets in pediatric systemic lupus erythematosus
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Immunology"
DOI: 10.1016/j.molimm.2018.01.003
Abstract: HIGHLIGHTSApoptotic and necrotic CD4+T cells are associated with plasma cell free DNA in pediatric SLE.Ds‐ISD induces MDM2 expression in human renal mesangial cells.MDM2 promotes cell proliferation in human renal mesangial cells.MDM2 alters peripheral B cells… read more here.
Keywords: human renal; dna; mdm2; proliferation ... See more keywords
Apoptosis-inducing effects of Terminalia phanerophlebia leaf extracts on human renal cells
Sign Up to like & getrecommendations! Published in 2021 at "South African Journal of Botany"
DOI: 10.1016/j.sajb.2021.03.009
Abstract: Abstract The study investigated the toxicogenic effects and molecular mechanisms of Terminalia phanerophlebia on human renal cells. The methylthiazol tetrazolium (MTT) assay was used to assess the cytotoxicity of a crude leaf extract of Terminalia… read more here.
Keywords: human renal; terminalia phanerophlebia; renal cells; apoptosis inducing ... See more keywords
The antitumor activity of umbelliferone in human renal cell carcinoma via regulation of the p110γ catalytic subunit of PI3Kγ
Sign Up to like & getrecommendations! Published in 2019 at "Acta Pharmaceutica"
DOI: 10.2478/acph-2019-0004
Abstract: Abstract Umbelliferone exhibits extensive pharmacological activity, including anti-immunomodulatory, anti-inflammatory and antigenotoxicity activities. However, its antitumor properties still remain unclear in human renal cell carcinoma (RCC) cells. Our results have revealed that treatment of human RCC… read more here.
Keywords: human renal; renal cell; cell carcinoma; dose dependent ... See more keywords
Transcriptomic signatures responding to PKM2 activator TEPP-46 in the hyperglycemic human renal proximal epithelial tubular cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.965379
Abstract: Pyruvate kinase M2 (PKM2), as the terminal and last rate-limiting enzyme of the glycolytic pathway, is an ideal enzyme for regulating metabolic phenotype. PKM2 tetramer activation has shown a protective role against diabetic kidney disease… read more here.
Keywords: renal proximal; human renal; pkm2; value ... See more keywords
Characteristics of Transfer RNA-Derived Fragments Expressed during Human Renal Cell Development: The Role of Dicer in tRF Biogenesis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073644
Abstract: tRNA-derived fragments participate in the regulation of many processes, such as gene silencing, splicing and translation in many organisms, ranging from bacteria to humans. We were interested to know how tRF abundance changes during the… read more here.
Keywords: derived fragments; dicer; renal cell; human renal ... See more keywords
Effect Assessment of Aurantio-Obtusin on Novel Human Renal Glomerular Endothelial Cells Model Using a Microfluidic Chip
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14214615
Abstract: Cassiae semen is widely used as a raw material of health food. Anthraquinone compounds, the main components in cassiae semen, have been reported to show nephrotoxicity. Aurantio-obtusin (AO) is a major anthraquinone compound extracted from… read more here.
Keywords: microfluidic chip; human renal; aurantio obtusin; glomerular endothelial ... See more keywords
Dysregulation of the mRNA Expression of Human Renal Drug Transporters by Proinflammatory Cytokines in Primary Human Proximal Tubular Epithelial Cells
Sign Up to like & getrecommendations! Published in 2024 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics16020285
Abstract: Proinflammatory cytokines, which are elevated during inflammation or infections, can affect drug pharmacokinetics (PK) due to the altered expression or activity of drug transporters and/or metabolizing enzymes. To date, such studies have focused on the… read more here.
Keywords: human renal; drug transporters; mrna expression; expression ... See more keywords
An Integrated Approach Involving Metabolomics and Transcriptomics Reveals Arsenic-Induced Toxicity in Human Renal Cells
Sign Up to like & getrecommendations! Published in 2025 at "Toxics"
DOI: 10.3390/toxics13060483
Abstract: Accumulating epidemiological evidence has indicated that arsenic exposure can lead to kidney injury. However, the underlying mechanisms of arsenic-induced nephrotoxicity have not been fully elucidated. In this study, the effect of sodium arsenite on the… read more here.
Keywords: human renal; arsenic exposure; arsenic induced; induced nephrotoxicity ... See more keywords
Primary Human Renal Proximal Tubular Epithelial Cells (pHRPTEpiCs): Shiga Toxin (Stx) Glycosphingolipid Receptors, Stx Susceptibility, and Interaction with Membrane Microdomains
Sign Up to like & getrecommendations! Published in 2021 at "Toxins"
DOI: 10.3390/toxins13080529
Abstract: Tubular epithelial cells of the human kidney are considered as targets of Shiga toxins (Stxs) in the Stx-mediated pathogenesis of hemolytic–uremic syndrome (HUS) caused by Stx-releasing enterohemorrhagic Escherichia coli (EHEC). Analysis of Stx-binding glycosphingolipids (GSLs)… read more here.
Keywords: human renal; epithelial cells; tubular epithelial; primary human ... See more keywords
Expression Profile of Human Renal Mesangial Cells Is Altered by Infection with Pathogenic Puumala Orthohantavirus
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14040823
Abstract: Acute kidney injury (AKI) with proteinuria is a hallmark of infections with Eurasian orthohantaviruses. Different kidney cells are identified as target cells of hantaviruses. Mesangial cells may play a central role in the pathogenesis of… read more here.
Keywords: mesangial cells; human renal; infection; profile ... See more keywords