Visualizing the interaction of Acanthamoeba castellanii with human retinal epithelial cells by spontaneous Raman and CARS imaging
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Raman Spectroscopy"
DOI: 10.1002/jrs.5296
Abstract: Improved understanding of the mechanism of nutrient's uptake can enable targeted manipulation of nutrient sensing pathways in medically important pathogens to a greater degree than is currently possible. In this context, we present the use… read more here.
Keywords: human retinal; castellanii; acanthamoeba castellanii; spontaneous raman ... See more keywords
RNA-Seq reveals placental growth factor regulates the human retinal endothelial cell barrier integrity by transforming growth factor (TGF-β) signaling
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-020-03862-z
Abstract: Placental growth factor (PlGF or PGF) is a member of the VEGF (vascular endothelial growth factor) family. It plays a pathological role in inflammation, vascular permeability, and pathological angiogenesis. The molecular signaling by which PlGF… read more here.
Keywords: human retinal; cell; placental growth; growth factor ... See more keywords
Apocynin ameliorates NADPH oxidase 4 (NOX4) induced oxidative damage in the hypoxic human retinal Müller cells and diabetic rat retina.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and cellular biochemistry"
DOI: 10.1007/s11010-021-04071-y
Abstract: NADPH oxidase (NOX) is a main producers of reactive oxygen species (ROS) that may contribute to the early pathogenesis of diabetic retinopathy (DR). ROS has harmful effects on endogenous neuro-survival factors brain-derived neurotrophic factor (BDNF)… read more here.
Keywords: human retinal; nox4 induced; bdnf sirt1; nadph oxidase ... See more keywords
Human retinal model systems: Strengths, weaknesses, and future directions.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental biology"
DOI: 10.1016/j.ydbio.2021.09.001
Abstract: The retina is a complex neuronal structure that converts light energy into visual perception. Many specialized aspects of the primate retina, including a cone rich macula for high acuity vision, ocular size, and cell type… read more here.
Keywords: human retinal; model systems; weaknesses future; model ... See more keywords
Lutein Activates the Transcription Factor Nrf2 in Human Retinal Pigment Epithelial Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.7b01929
Abstract: The degeneration of the retinal pigment epithelium caused by oxidative damage is a stage of development in age-related macular degeneration (AMD). The carotenoid lutein is a major macular pigment that may reduce the incidence and… read more here.
Keywords: factor nrf2; human retinal; pigment epithelial; pigment ... See more keywords
Sulodexide reduces glucose induced senescence in human retinal endothelial cells
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-90987-w
Abstract: Chronic exposure of retinal endothelium cells to hyperglycemia is the leading cause of diabetic retinopathy. We evaluated the effect of high glucose concentration on senescence in human retinal endothelial cells (HREC) and modulation of that… read more here.
Keywords: human retinal; hrec; senescence; endothelial cells ... See more keywords
Regulation of molecular clock oscillations and phagocytic activity via muscarinic Ca2+ signaling in human retinal pigment epithelial cells
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep44175
Abstract: Vertebrate eyes are known to contain circadian clocks, however, the intracellular mechanisms regulating the retinal clockwork remain largely unknown. To address this, we generated a cell line (hRPE-YC) from human retinal pigmental epithelium, which stably… read more here.
Keywords: human retinal; clock oscillations; rhythms; molecular clock ... See more keywords
Electrical responses from human retinal cone pathways associate with a common genetic polymorphism implicated in myopia
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2119675119
Abstract: Significance Myopia prevalence has increased dramatically over recent decades. Genome-wide association studies have identified numerous loci, but mechanisms by which genotypic identity confers myopia susceptibility are unknown. The common variant most strongly associated with myopia… read more here.
Keywords: electrical responses; cone; myopia; responses human ... See more keywords
Expression Analysis of the Circular RNA Molecules in the Human Retinal Cells Treated with Homocysteine
Sign Up to like & getrecommendations! Published in 2019 at "Current Eye Research"
DOI: 10.1080/02713683.2018.1542005
Abstract: ABSTRACT Purpose: To characterize the global profile of circular RNAs (circRNAs) and their differential expression levels in homocysteine (Hcy)-treated ARPE-19 cells, a line of human retinal pigment epithelial (RPE) cells. Materials and Methods: We treated… read more here.
Keywords: hcy; human retinal; circular rna; expression ... See more keywords
Expression of Long Non-Coding RNAs in Activated Human Retinal Vascular Endothelial Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Ocular immunology and inflammation"
DOI: 10.1080/09273948.2022.2122512
Abstract: PURPOSE Retinal endothelial cell activation is a central event in non-infectious posterior uveitis. There is recent interest in long non-coding (lnc)RNA-targeted therapeutics for retinal diseases. We aimed to identify human retinal endothelial cell lncRNAs that… read more here.
Keywords: long non; endothelial cells; expression; human retinal ... See more keywords
Carnosol attenuates high glucose damage in human retinal endothelial cells through regulation of ERK/Nrf2/HO-1 pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Asian natural products research"
DOI: 10.1080/10286020.2022.2137022
Abstract: Carnosol is a natural compound with antioxidant properties. Based on this evidence, in the present study we investigated whether this compound can protect retinal vascular endothelium from hyperglycemic insult responsible for diabetic retinopathy development. We… read more here.
Keywords: damage; endothelial cells; high glucose; human retinal ... See more keywords