LAUSR

Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis.

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1 Published in 2021 at "Nature communications"

DOI: 10.1038/s41467-021-27032-x

Abstract: The ancestral origins of the lytic cell death mode, necroptosis, lie in host defense. However, the dysregulation of necroptosis in inflammatory diseases has led to widespread interest in targeting the pathway therapeutically. This mode of… read more here.

Keywords: mlkl; necroptosis; human ripk3; ripk3 ... See more keywords