Modeling human RNA spliceosome mutations in the mouse: not all mice were created equal.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental hematology"
DOI: 10.1016/j.exphem.2018.11.001
Abstract: Myelodysplastic syndromes (MDS) and related myelodysplastic/myeloproliferative neoplasms (MDS/MPNs) are clonal stem cell disorders, primarily affecting patients over 65 years of age. Mapping of the MDS and MDS/MPN genome identified recurrent heterozygous mutations in the RNA… read more here.
Keywords: murine models; modeling human; human rna; sf3b1 srsf2 ... See more keywords
The Nonbulky DNA Lesions Spiroiminodihydantoin and 5-Guanidinohydantoin Significantly Block Human RNA Polymerase II Elongation in Vitro.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry"
DOI: 10.1021/acs.biochem.7b00295
Abstract: The most common, oxidatively generated lesion in cellular DNA is 8-oxo-7,8-dihydroguanine, which can be oxidized further to yield highly mutagenic spiroiminodihydantoin (Sp) and 5-guanidinohydantoin (Gh) in DNA. In human cell-free extracts, both lesions can be… read more here.
Keywords: block human; dna; human rna; rna ... See more keywords
Overcoming challenges in human saliva gene expression measurements
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-67825-6
Abstract: Saliva, as a non-invasive and easily accessible biofluid, has been shown to contain RNA biomarkers for prediction and diagnosis of several diseases. However, systematic analysis done by our group identified two problematic issues not coherently… read more here.
Keywords: human rna; rna; gene expression; pre amplification ... See more keywords
Differential dependencies of human RNA polymerase II promoters on TBP, TAF1, TFIIB and XPB
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac678
Abstract: Abstract The effects of rapid acute depletion of components of RNA polymerase II (Pol II) general transcription factors (GTFs) that are thought to be critical for formation of preinitiation complexes (PICs) and initiation in vitro… read more here.
Keywords: polymerase; differential dependencies; rna polymerase; human rna ... See more keywords
Global Analysis of the Human RNA Degradome Reveals Widespread Decapped and Endonucleolytic Cleaved Transcripts
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21186452
Abstract: RNA decay is an important regulatory mechanism for gene expression at the posttranscriptional level. Although the main pathways and major enzymes that facilitate this process are well defined, global analysis of RNA turnover remains under-investigated.… read more here.
Keywords: human rna; global analysis; analysis; rna ... See more keywords
Vectorial Release of Human RNA Viruses from Epithelial Cells
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14020231
Abstract: Epithelial cells are apico-basolateral polarized cells that line all tubular organs and are often targets for infectious agents. This review focuses on the release of human RNA virus particles from both sides of polarized human… read more here.
Keywords: human rna; release human; release; epithelial cells ... See more keywords