Novel dominant and recessive variants in human ROBO1 cause distinct neurodevelopmental defects through different mechanisms.
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DOI: 10.1093/hmg/ddac070
Abstract: The Roundabout (Robo) receptors, located on growth cones of neurons, induce axon repulsion in response to the extracellular ligand Slit. The Robo family of proteins controls midline crossing of commissural neurons during development in flies.… read more here.
Keywords: human robo1; robo1; t2a gal4; variants human ... See more keywords