Human SARS-CoV-2 challenge uncovers local and systemic response dynamics
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DOI: 10.1038/s41586-024-07575-x
Abstract: The COVID-19 pandemic is an ongoing global health threat, yet our understanding of the dynamics of early cellular responses to this disease remains limited1. Here in our SARS-CoV-2 human challenge study, we used single-cell multi-omics… read more here.
Keywords: sars cov; cov challenge; response; infection ... See more keywords
Human-SARS-CoV-2 interactome and human genetic diversity: TMPRSS2-rs2070788, associated with severe influenza, and its population genetics caveats in Native Americans
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DOI: 10.1590/1678-4685-gmb-2020-0484
Abstract: Abstract For human/SARS-CoV-2 interactome genes ACE2, TMPRSS2 and BSG, there is a convincing evidence of association in Asians with influenza-induced SARS for TMPRSS2-rs2070788, tag-SNP of the eQTL rs383510. This case illustrates the importance of population… read more here.
Keywords: rs2070788; cov interactome; human sars; genetics ... See more keywords
Understanding Mutations in Human SARS-CoV-2 Spike Glycoprotein: A Systematic Review & Meta-Analysis
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DOI: 10.3390/v15040856
Abstract: Genetic variant(s) of concern (VoC) of SARS-CoV-2 have been emerging worldwide due to mutations in the gene encoding spike glycoprotein. We performed comprehensive analyses of spike protein mutations in the significant variant clade of SARS-CoV-2,… read more here.
Keywords: spike glycoprotein; understanding mutations; mutations human; sars cov ... See more keywords