Use of Organ Dysfunction as A Primary Outcome Variable Following Cecal Ligation and Puncture: Recommendations for Future Studies.
Sign Up to like & getrecommendations! Published in 2019 at "Shock"
DOI: 10.1097/shk.0000000000001485
Abstract: Outcomes variables for research on sepsis have centered on mortality and changes in the host immune response. However, a recent task force (Sepsis-3) revised the definition of sepsis to "life-threatening organ dysfunction caused by a… read more here.
Keywords: sepsis; ligation puncture; organ dysfunction; human sepsis ... See more keywords
Of mice and men: Laboratory murine models for recapitulating the immunosuppression of human sepsis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.956448
Abstract: Prolonged immunosuppression is increasingly recognized as the major cause of late phase and long-term mortality in sepsis. Numerous murine models with different paradigms, such as lipopolysaccharide injection, bacterial inoculation, and barrier disruption, have been used… read more here.
Keywords: sepsis; immunopathology; human sepsis; murine models ... See more keywords