Human Sirtuin Regulators: The “Success” Stories
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.752117
Abstract: The human sirtuins are a group of NAD+-dependent protein deacylases. They “erase” acyl modifications from lysine residues in various cellular targets including histones, transcription factors, and metabolic enzymes. Through these far-reaching activities, sirtuins regulate a… read more here.
Keywords: human sirtuin; human sirtuins; sirtuin regulators; success stories ... See more keywords
Human sirtuin 2 inhibitors, their mechanisms and binding modes.
Sign Up to like & getrecommendations! Published in 2023 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2022-0253
Abstract: The silent information regulator (sirtuin) is a family of enzymes involved in epigenetic processes with lysine deacetylase activity, having as substrates histones and other proteins. They participate in a wide range of cellular and pathologic… read more here.
Keywords: modes human; human sirtuin; mechanisms binding; inhibitors mechanisms ... See more keywords