PiRNAs, PiRNA‐Like, and PIWI Proteins in Somatic Cells: From Genetic Regulation to Disease Mechanisms
Sign Up to like & getrecommendations! Published in 2025 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.70012
Abstract: PIWI‐interacting RNAs (piRNAs) are small non‐coding RNA molecules that were originally described as responsible for binding to PIWI proteins to silence transposons in the germline genome. Here we discuss their controversial influence in regulating gene… read more here.
Keywords: human somatic; non coding; somatic cells; pirna like ... See more keywords
Tracking and Predicting Human Somatic Cell Reprogramming Using Nuclear Characteristics.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical journal"
DOI: 10.1016/j.bpj.2019.10.014
Abstract: Reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) generates valuable resources for disease modeling, toxicology, cell therapy, and regenerative medicine. However, the reprogramming process can be stochastic and inefficient, creating many partially… read more here.
Keywords: somatic cell; human somatic; tracking predicting; predicting human ... See more keywords
The mutational landscape of human somatic and germline cells.
Sign Up to like & getrecommendations! Published in 2021 at "Nature"
DOI: 10.1038/s41586-021-03822-7
Abstract: Over the course of an individual's lifetime, normal human cells accumulate mutations1. Here we compare the mutational landscape in 29 cell types from the soma and germline using multiple samples from the same individuals. Two… read more here.
Keywords: mutational landscape; human somatic; landscape; cell types ... See more keywords
Chemical reprogramming of human somatic cells to pluripotent stem cells.
Sign Up to like & getrecommendations! Published in 2022 at "Nature"
DOI: 10.1038/s41586-022-04593-5
Abstract: Cellular reprogramming can manipulate the identity of cells to generate the desired cell types1-3. The use of cell intrinsic components, including oocyte cytoplasm and transcription factors, can enforce somatic cell reprogramming to pluripotent stem cells4-7.… read more here.
Keywords: chemical reprogramming; pluripotent stem; human somatic; stem cells ... See more keywords
Mitochondrial DNA mosaicism in normal human somatic cells
Sign Up to like & getrecommendations! Published in 2024 at "Nature Genetics"
DOI: 10.1038/s41588-024-01838-z
Abstract: Somatic cells accumulate genomic alterations with age; however, our understanding of mitochondrial DNA (mtDNA) mosaicism remains limited. Here we investigated the genomes of 2,096 clones derived from three cell types across 31 donors, identifying 6,451… read more here.
Keywords: human somatic; dna mosaicism; mosaicism; somatic cells ... See more keywords
Direct Reprogramming of Adult Human Somatic Stem Cells Into Functional Neurons Using Sox2, Ascl1, and Neurog2
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2018.00155
Abstract: Reprogramming of somatic cells into induced pluripotent stem cells (iPS) or directly into cells from a different lineage, including neurons, has revolutionized research in regenerative medicine in recent years. Mesenchymal stem cells are good candidates… read more here.
Keywords: human somatic; stem; stem cells; sox2 ascl1 ... See more keywords