Tracking and Predicting Human Somatic Cell Reprogramming Using Nuclear Characteristics.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical journal"
DOI: 10.1016/j.bpj.2019.10.014
Abstract: Reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) generates valuable resources for disease modeling, toxicology, cell therapy, and regenerative medicine. However, the reprogramming process can be stochastic and inefficient, creating many partially… read more here.
Keywords: somatic cell; human somatic; tracking predicting; predicting human ... See more keywords
The mutational landscape of human somatic and germline cells.
Sign Up to like & getrecommendations! Published in 2021 at "Nature"
DOI: 10.1038/s41586-021-03822-7
Abstract: Over the course of an individual's lifetime, normal human cells accumulate mutations1. Here we compare the mutational landscape in 29 cell types from the soma and germline using multiple samples from the same individuals. Two… read more here.
Keywords: mutational landscape; human somatic; landscape; cell types ... See more keywords
Chemical reprogramming of human somatic cells to pluripotent stem cells.
Sign Up to like & getrecommendations! Published in 2022 at "Nature"
DOI: 10.1038/s41586-022-04593-5
Abstract: Cellular reprogramming can manipulate the identity of cells to generate the desired cell types1-3. The use of cell intrinsic components, including oocyte cytoplasm and transcription factors, can enforce somatic cell reprogramming to pluripotent stem cells4-7.… read more here.
Keywords: chemical reprogramming; pluripotent stem; human somatic; stem cells ... See more keywords
Direct Reprogramming of Adult Human Somatic Stem Cells Into Functional Neurons Using Sox2, Ascl1, and Neurog2
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2018.00155
Abstract: Reprogramming of somatic cells into induced pluripotent stem cells (iPS) or directly into cells from a different lineage, including neurons, has revolutionized research in regenerative medicine in recent years. Mesenchymal stem cells are good candidates… read more here.
Keywords: human somatic; stem; stem cells; sox2 ascl1 ... See more keywords