Constructing Linear‐Oriented Pre‐Vascularized Human Spinal Cord Tissues for Spinal Cord Injury Repair
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202303388
Abstract: Repairing spinal cord injury (SCI) is a global medical challenge lacking effective clinical treatment. Developing human‐engineered spinal cord tissues that can replenish lost cells and restore a regenerative microenvironment offers promising potential for SCI therapy.… read more here.
Keywords: cord; spinal cord; cord injury; cord tissues ... See more keywords
Measurements and morphometric landmarks of the human spinal cord: A cadaveric study
Sign Up to like & getrecommendations! Published in 2023 at "Clinical Anatomy"
DOI: 10.1002/ca.24010
Abstract: The topographical neuroanatomy of the human spinal cord (SC) is currently based on the adjacent vertebrae. This morphometric study sought to develop a dataset allowing for statistical analysis of human SC segment characteristics. Overall, 32… read more here.
Keywords: measurements morphometric; human spinal; widths thicknesses; spinal cord ... See more keywords
Automated slice‐specific z‐shimming for functional magnetic resonance imaging of the human spinal cord
Sign Up to like & getrecommendations! Published in 2022 at "Human Brain Mapping"
DOI: 10.1002/hbm.26018
Abstract: Functional magnetic resonance imaging (fMRI) of the human spinal cord faces many challenges, such as signal loss due to local magnetic field inhomogeneities. This issue can be addressed with slice‐specific z‐shimming, which compensates for the… read more here.
Keywords: magnetic resonance; resonance imaging; slice specific; human spinal ... See more keywords
Investigating the human spinal sensorimotor pathways through functional magnetic resonance imaging
Sign Up to like & getrecommendations! Published in 2021 at "NeuroImage"
DOI: 10.1016/j.neuroimage.2021.118684
Abstract: Most of our knowledge about the human spinal ascending (sensory) and descending (motor) pathways comes from non-invasive electrophysiological investigations. However, recent methodological advances in acquisition and analyses of functional magnetic resonance imaging (fMRI) data from… read more here.
Keywords: resonance imaging; magnetic resonance; spinal fmri; human spinal ... See more keywords
Non-invasive recording of high-frequency signals from the human spinal cord
Sign Up to like & getrecommendations! Published in 2022 at "NeuroImage"
DOI: 10.1016/j.neuroimage.2022.119050
Abstract: Throughout the somatosensory system, neuronal ensembles generate high-frequency signals in the range of several hundred Hertz in response to sensory input. High-frequency signals have been related to neuronal spiking, and could thus help clarify the… read more here.
Keywords: human spinal; high frequency; spinal cord; frequency signals ... See more keywords
Decoding the spatiotemporal regulation of transcription factors during human spinal cord development
Sign Up to like & getrecommendations! Published in 2024 at "Cell Research"
DOI: 10.1038/s41422-023-00897-x
Abstract: The spinal cord is a crucial component of the central nervous system that facilitates sensory processing and motor performance. Despite its importance, the spatiotemporal codes underlying human spinal cord development have remained elusive. In this… read more here.
Keywords: cord; spinal cord; cord development; transcription ... See more keywords
Production of human spinal-cord organoids recapitulating neural-tube morphogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Nature biomedical engineering"
DOI: 10.1038/s41551-022-00868-4
Abstract: Human spinal-cord-like tissues induced from human pluripotent stem cells are typically insufficiently mature and do not mimic the morphological features of neurulation. Here, we report a three-dimensional culture system and protocol for the production of… read more here.
Keywords: human spinal; cord; morphogenesis; spinal cord ... See more keywords
Acute and non-resolving inflammation associate with oxidative injury after human spinal cord injury
Sign Up to like & getrecommendations! Published in 2021 at "Brain"
DOI: 10.1093/brain/awaa360
Abstract: In spinal cord injury, the initial mechanical insult may be followed by progressive cord atrophy and neurodegeneration. Zrzavy et al. characterize innate and adaptive inflammatory responses in human spinal cord injury, and show that oxidative… read more here.
Keywords: cord; oxidative injury; human spinal; injury ... See more keywords
Historical development and contemporary use of neuromodulation in human spinal cord injury
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Neurology"
DOI: 10.1097/wco.0000000000001080
Abstract: Purpose of review There is a long history of neuromodulation of the spinal cord after injury in humans with recent momentum of studies showing evidence for therapeutic potential. Nonrandomized, mechanistic, hypothesis-driven, small cohort, epidural stimulation… read more here.
Keywords: neuromodulation; human spinal; cord injury; spinal cord ... See more keywords
Constructing 2D maps of human spinal cord activity and isolating the functional midline with high-density microelectrode arrays
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abq4744
Abstract: Intraoperative neuromonitoring (IONM) is a widely used practice in spine surgery for early detection and minimization of neurological injury. IONM is most commonly conducted by indirectly recording motor and somatosensory evoked potentials from either muscles… read more here.
Keywords: cord; ionm; human spinal; spinal cord ... See more keywords
CSF outflow from the human spinal canal: preliminary results from an anatomical specimen-based model
Sign Up to like & getrecommendations! Published in 2025 at "Fluids and Barriers of the CNS"
DOI: 10.1186/s12987-025-00645-w
Abstract: Recent discoveries focused on the role of cerebrospinal fluid (CSF) in metabolite clearance have initiated intense research on CSF circulation and outflow pathways. These studies have focused on the cranial subarachnoid space, whereas spinal outflow… read more here.
Keywords: csf outflow; anatomical specimen; preliminary results; csf ... See more keywords