Bioactive surfaces from seaweed-derived alginates for the cultivation of human stem cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Applied Phycology"
DOI: 10.1007/s10811-017-1130-6
Abstract: Nowadays, modern approaches in tissue engineering include the combination of therapeutic relevant cells with high quality, biocompatible biomaterials. The resulting cellularized scaffolds are of great interest for several pharmaceutical applications such as drug screening/discovery, disease… read more here.
Keywords: cultivation human; surfaces seaweed; bioactive surfaces; stem ... See more keywords
Pharmacological profile of vascular activity of human stem villous arteries.
Sign Up to like & getrecommendations! Published in 2019 at "Placenta"
DOI: 10.1016/j.placenta.2019.09.009
Abstract: INTRODUCTION The function of the placental vasculature differs considerably from other systemic vascular beds of the human body. A detailed understanding of the normal placental vascular physiology is the foundation to understand perturbed conditions potentially… read more here.
Keywords: stem villous; vasculature; villous arteries; pharmacological profile ... See more keywords
Role of the Internal Limiting Membrane in Structural Engraftment and Topographic Spacing of Transplanted Human Stem Cell-Derived Retinal Ganglion Cells
Sign Up to like & getrecommendations! Published in 2020 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2020.12.001
Abstract: Summary Retinal ganglion cell (RGC) replacement holds potential for restoring vision lost to optic neuropathy. Transplanted RGCs must undergo neuroretinal integration to receive afferent visual signals for processing and efferent transmission. To date, retinal integration… read more here.
Keywords: retinal ganglion; stem cell; cell; human stem ... See more keywords
Stronger Cytotoxicity for Cancer Cells Than for Fast Proliferating Human Stem Cells by Rationally Designed Dinuclear Complexes.
Sign Up to like & getrecommendations! Published in 2020 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.0c02255
Abstract: Cytostatic metallo-drugs mostly bind to the nucleobases of DNA. A new family of dinuclear transition metal complexes was rationally designed to selectively target the phosphate diesters of the DNA backbone by covalent bonding. The synthesis… read more here.
Keywords: dinuclear complexes; rationally designed; cancer cells; cancer ... See more keywords
FRESH 3D bioprinting a contractile heart tube using human stem cell-derived cardiomyocytes
Sign Up to like & getrecommendations! Published in 2022 at "Biofabrication"
DOI: 10.1088/1758-5090/ac58be
Abstract: Here we report the 3D bioprinting of a simplified model of the heart, similar to that observed in embryonic development, where the heart is a linear tube that pumps blood and nutrients to the growing… read more here.
Keywords: using human; heart tube; heart; tube using ... See more keywords
Potential Involvement of BIRC5 in Maintaining Pluripotency and Cell Differentiation of Human Stem Cells
Sign Up to like & getrecommendations! Published in 2019 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2019/8727925
Abstract: The BIRC5 gene encodes a survivin protein belonging to class III of inhibitors of apoptosis, IAP. This protein serves a dual role. First, it regulates cell death, and second, it is an important regulator of… read more here.
Keywords: cell; expression; birc5; stem ... See more keywords
Construction of recombinant lentiviral vector containing human stem cell leukemia gene and its expression in interstitial cells of cajal
Sign Up to like & getrecommendations! Published in 2019 at "Open Life Sciences"
DOI: 10.1515/biol-2020-0010
Abstract: Abstract This study aims to construct recombinant lentiviral vectors containing the human stem cell leukemia (SCL) gene and investigate their in vitro transfection efficiency in Interstitial Cells of Cajal (ICC) of guinea pig bladders. In… read more here.
Keywords: containing human; recombinant lentiviral; gene; human stem ... See more keywords
Cardiac Safety of Kinase Inhibitors – Improving Understanding and Prediction of Liabilities in Drug Discovery Using Human Stem Cell-Derived Models
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2021.639824
Abstract: Many small molecule kinase inhibitors (SMKIs) used to fight cancer have been associated with cardiotoxicity in the clinic. Therefore, preventing their failure in clinical development is a priority for preclinical discovery. Our study focused on… read more here.
Keywords: kinase inhibitors; cell derived; stem cell; cell ... See more keywords
Pharmacological Profile of the Sodium Current in Human Stem Cell-Derived Cardiomyocytes Compares to Heterologous Nav1.5+β1 Model
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2019.01374
Abstract: The cardiac Nav1.5 mediated sodium current (INa) generates the upstroke of the action potential in atrial and ventricular myocytes. Drugs that modulate this current can therefore be antiarrhythmic or proarrhythmic, which requires preclinical evaluation of… read more here.
Keywords: sodium current; class; cell derived; stem cell ... See more keywords
Comparison of the Simulated Response of Three in Silico Human Stem Cell-Derived Cardiomyocytes Models and in Vitro Data Under 15 Drug Actions
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.604713
Abstract: Objectives: Improvements in human stem cell-derived cardiomyocyte (hSC-CM) technology have promoted their use for drug testing and disease investigations. Several in silico hSC-CM models have been proposed to augment interpretation of experimental findings through simulations.… read more here.
Keywords: cell derived; silico; drug; stem cell ... See more keywords
Modelling Lyssavirus Infections in Human Stem Cell-Derived Neural Cultures
Sign Up to like & getrecommendations! Published in 2020 at "Viruses"
DOI: 10.3390/v12040359
Abstract: Rabies is a zoonotic neurological infection caused by lyssavirus that continues to result in devastating loss of human life. Many aspects of rabies pathogenesis in human neurons are not well understood. Lack of appropriate ex-vivo… read more here.
Keywords: stem cell; human stem; cell derived; neural cultures ... See more keywords