Identification of α‐Mangostin as an Agonist of Human STING
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DOI: 10.1002/cmdc.201800481
Abstract: The xanthone derivate 5′,6′‐dimethylxanthenone‐4‐acetic acid (DMXAA, also known as ASA404 or vadimezan) is a potent agonist of murine STING (stimulator of interferon genes), but cannot activate human STING. Herein we report that α‐mangostin, which bears… read more here.
Keywords: mangostin agonist; human sting; identification mangostin; agonist human ... See more keywords
Generation and Characterization of Human-Mouse STING Chimeras That Allow DENV Replication in Mouse Cells
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DOI: 10.1128/msphere.00914-21
Abstract: This article characterizes the interaction between human STING and DENV viral protease complex NS2B3 by constructing serial deletion mutants of STING. Our findings suggest that DENV nonstructural protein NS2B interacts with the transmembrane domains and… read more here.
Keywords: human mouse; denv replication; mouse sting; mouse ... See more keywords
Abstract B43: Novel small-molecule human STING agonists generate robust Type I interferon responses in tumors
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DOI: 10.1158/2326-6074.tumimm17-b43
Abstract: Background: A significant proportion of human cancers grow unchecked by the immune system. These cold or non-inflamed tumors do not have a T cell infiltrate and it has been shown that activation of innate immune… read more here.
Keywords: crd 100; human sting; small molecule; sting agonists ... See more keywords