Co-exposure of cannabinoids with amphetamines and biological, behavioural and health outcomes: a scoping review of animal and human studies.
Sign Up to like & getrecommendations! Published in 2021 at "Psychopharmacology"
DOI: 10.1007/s00213-021-05960-2
Abstract: RATIONALE The growing prevalence of psychostimulant (including amphetamine) use and associated health harms, with limited treatment options, present a global challenge. There is an increasing availability and medical applications of cannabinoids, and growing interest in… read more here.
Keywords: amphetamine; scoping review; use; human studies ... See more keywords
Oxytocin facilitates adaptive fear and attenuates anxiety responses in animal models and human studies—potential interaction with the corticotropin-releasing factor (CRF) system in the bed nucleus of the stria terminalis (BNST)
Sign Up to like & getrecommendations! Published in 2018 at "Cell and Tissue Research"
DOI: 10.1007/s00441-018-2889-8
Abstract: Despite its relatively well-understood role as a reproductive and pro-social peptide, oxytocin (OT) tells a more convoluted story in terms of its modulation of fear and anxiety. This nuanced story has been obscured by a… read more here.
Keywords: fear; anxiety; human studies; models human ... See more keywords
Role of 27-hydroxycholesterol and its metabolism in cancer progression: human studies.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2021.114618
Abstract: Direct translation of findings achieved in experimental cell or animal models to humans is quite a difficult task. We focused here only on the epidemiological and ex vivo human studies so far available about the… read more here.
Keywords: role hydroxycholesterol; metabolism cancer; human studies; role ... See more keywords
Citrulline in health and disease. Review on human studies.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical nutrition"
DOI: 10.1016/j.clnu.2017.10.009
Abstract: The amino acid L-citrulline (CIT) is safely used from the neonatal period onwards in those with urea cycle defects and carbamyl phosphate synthetase or ornithine transcarbamylase deficiencies, but several lines of enquiry indicate that it… read more here.
Keywords: citrulline health; disease; disease review; human studies ... See more keywords
Association of cannabinoid receptor modulation with normal and abnormal skeletal remodelling: A systematic review and meta-analysis of in vitro, in vivo and human studies.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2021.105928
Abstract: To address the inconsistent findings from studies that used different models to explore the role of classical cannabinoid type 1 (CB1) and 2 (CB2) receptors in skeletal remodelling, we searched Medline, Web of Science and… read more here.
Keywords: skeletal remodelling; vitro vivo; bone; human studies ... See more keywords
Safeguards for human studies can’t cope with big data
Sign Up to like & getrecommendations! Published in 2019 at "Nature"
DOI: 10.1038/d41586-019-01164-z
Abstract: Forty years on from a foundational report on how to protect people participating in research, cracks are showing, warns Nathaniel Raymond.Forty years on from a foundational report on how to protect people participating in research,… read more here.
Keywords: big data; cope big; studies cope; safeguards human ... See more keywords
Tea and bone health: Findings from human studies, potential mechanisms, and identification of knowledge gaps
Sign Up to like & getrecommendations! Published in 2017 at "Critical Reviews in Food Science and Nutrition"
DOI: 10.1080/10408398.2014.1001019
Abstract: ABSTRACT The population of the developed world is aging. With this aging population, strategies for prevention rather than treatment of chronic disease, such as osteoporosis, are essential for preserving quality of life and reducing health… read more here.
Keywords: knowledge gaps; bone health; potential mechanisms; human studies ... See more keywords
Prevention of colistin induced nephrotoxicity: a review of preclinical and clinical data
Sign Up to like & getrecommendations! Published in 2021 at "Expert Review of Clinical Pharmacology"
DOI: 10.1080/17512433.2021.1933436
Abstract: ABSTRACT Introduction: The emergence of antimicrobial resistance in Gram-negative bacteria is a concerning challenge for health systems. The polymyxins, including colistin, are one of the limited available options these pathogens management. Nephrotoxicity, beside neurotoxicity is… read more here.
Keywords: colistin; human studies; colistin induced; review ... See more keywords
What have humans done for evolutionary biology? Contributions from genes to populations
Sign Up to like & getrecommendations! Published in 2017 at "Proceedings of the Royal Society B: Biological Sciences"
DOI: 10.1098/rspb.2017.1164
Abstract: Many fundamental concepts in evolutionary biology were discovered using non-human study systems. Humans are poorly suited to key study designs used to advance this field, and are subject to cultural, technological, and medical influences often… read more here.
Keywords: done evolutionary; evolutionary biology; human studies; humans done ... See more keywords
Study design considerations to assess the impact of potential drug–drug interactions in first‐in‐human studies in oncology drug development
Sign Up to like & getrecommendations! Published in 2023 at "Clinical and Translational Science"
DOI: 10.1111/cts.13496
Abstract: First-in-human studies are limited to patients with serious diseases for which no curative therapies are available to ensure that the benefits outweigh the risks. However, many patients receive medications that are either victims or perpetrators… read more here.
Keywords: oncology; drug interactions; drug drug; human studies ... See more keywords
Assessment of the Potential for Veverimer Drug-Drug Interactions
Sign Up to like & getrecommendations! Published in 2021 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.121.000366
Abstract: Veverimer is a polymer being developed as a potential treatment of metabolic acidosis in patients with chronic kidney disease. Veverimer selectively binds and removes hydrochloric acid from the gastrointestinal tract, resulting in an increase in… read more here.
Keywords: gastrointestinal tract; drug interactions; drug; human studies ... See more keywords