Ibuprofen inhibits human sweet taste and glucose detection implicating an additional mechanism of metabolic disease risk reduction
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DOI: 10.1111/bph.70004
Abstract: The human sweet taste receptor, TAS1R2–TAS1R3, conveys sweet taste in the mouth and may help regulate glucose metabolism throughout the body. Ibuprofen and naproxen are structurally similar to known inhibitors of TAS1R2–TAS1R3 and have been… read more here.
Keywords: ibuprofen inhibits; inhibits human; taste; human sweet ... See more keywords
Exploring the Molecular Interactions between Neoculin and the Human Sweet Taste Receptors Through Computational Approaches
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DOI: 10.17576/jsm-2020-4903-06
Abstract: Neoculin is a sweet taste protein capable of modifying sour taste into sweet taste. Neoculin, along with other sweeteners, are received by the human sweet taste receptors T1R2 and T1R3. To date, there has been… read more here.
Keywords: taste; taste receptors; sweet taste; human sweet ... See more keywords
A Dynamic Mass Redistribution Assay for the Human Sweet Taste Receptor Uncovers G-Protein Dependent Biased Ligands
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.832529
Abstract: The sweet taste receptor is rather unique, recognizing a diverse repertoire of natural or synthetic ligands, with a surprisingly large structural diversity, and with potencies stretching over more than six orders of magnitude. Yet, it… read more here.
Keywords: human sweet; taste receptor; assay human; receptor ... See more keywords