Dolichosin A, a coumestan isolated from Glycine tabacina, inhibits IL-1β-induced inflammation in SW982 human synovial cells and suppresses RANKL-induced osteoclastogenesis: From network pharmacology to experimental pharmacology.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.112855
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Glycine tabacina (Labill.) Benth has been used as a traditional Chinese herbal medicine for the treatment of rheumatoid arthritis (RA) and joint infection. It is also one of the sources of the renowned… read more here.
Keywords: medicine; network; pharmacology; sw982 human ... See more keywords
Extra-virgin olive oil phenols hydroxytyrosol and hydroxytyrosol acetate, down-regulate the production of mediators involved in joint erosion in human synovial cells
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DOI: 10.1016/j.jff.2017.06.041
Abstract: Abstract The hallmark of rheumatoid arthritis (RA) pathology is characterized by both hyperproliferation of synovial fibroblasts (SFs) and massive infiltration of inflammatory immune cells. This study was conducted to evaluate the efficacy of hydroxytyrosol (HTy)… read more here.
Keywords: production; hydroxytyrosol acetate; hty; hty hty ... See more keywords
IGF-1 Gene Transfer to Human Synovial MSCs Promotes Their Chondrogenic Differentiation Potential without Induction of the Hypertrophic Phenotype
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DOI: 10.1155/2017/5804147
Abstract: Mesenchymal stem cell- (MSC-) based therapy is a promising treatment for cartilage. However, repair tissue in general fails to regenerate an original hyaline-like tissue. In this study, we focused on increasing the expression levels for… read more here.
Keywords: synovial mscs; chondrogenic differentiation; igf gene; mscs ... See more keywords
Early OA Stage Like Response Occurs after Dynamic Stretching of Human Synovial Fibroblasts
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DOI: 10.3390/ijms21113874
Abstract: As events triggering early osteoarthritis onset can be related to mechanical stress and proinflammatory signaling, we investigated the effect of different mechanical strain protocols on the expression of proinflammatory genes, as well as extracellular matrix… read more here.
Keywords: tension; term; tensile; strain ... See more keywords
The Electrochemical Behavior of Ti in Human Synovial Fluids
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DOI: 10.3390/ma15051726
Abstract: In this study, we report results of the interaction of titanium (Ti) with human synovial fluids. A wide palette of electrochemical techniques was used, including open circuit potential, potentiodynamic methods, and electrochemical impedance. After the… read more here.
Keywords: human synovial; electrochemical behavior; spectroscopy; chemistry ... See more keywords
Ginkgolide J protects human synovial cells SW982 via suppression of p38-dependent production of pro-inflammatory mediators
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DOI: 10.3892/mmr.2021.12194
Abstract: Fibroblast-like synoviocytes (FLS) in the synovial lining play a key role in the pathological process of rheumatoid arthritis (RA), which produce pro-inflammatory mediators to perpetuate inflammation and proteases to contribute to cartilage destruction. Ginkgolide J… read more here.
Keywords: production pro; inflammatory mediators; synovial cells; pro inflammatory ... See more keywords
Beclin1 overexpression suppresses tumor cell proliferation and survival via an autophagy-dependent pathway in human synovial sarcoma cells
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DOI: 10.3892/or.2018.6599
Abstract: Beclin1 is an important autophagy-related protein, which is involved in both autophagy and apoptosis. In recent years, the antitumor effect of Beclin1 has received increased attention. In the present study, we established a stable Beclin1-overexpressing… read more here.
Keywords: beclin1 overexpression; viability; cell; human synovial ... See more keywords