Dihydrolipoamide dehydrogenase suppression induces human tau phosphorylation by increasing whole body glucose levels in a C. elegans model of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Brain Research"
DOI: 10.1007/s00221-018-5341-0
Abstract: The microtubule associated tau protein becomes hyperphosphorylated in Alzheimer’s disease (AD). While hyperphosphorylation promotes neurodegeneration, the cause and consequences of this abnormal modification are poorly understood. As impaired energy metabolism is an important hallmark of… read more here.
Keywords: suppression; human tau; alzheimer disease; tau phosphorylation ... See more keywords
Age dependent trans-cellular propagation of human tau aggregates in Drosophila disease models
Sign Up to like & getrecommendations! Published in 2021 at "Brain Research"
DOI: 10.1016/j.brainres.2020.147207
Abstract: Tauopathies is a class of neurodegenerative disorders which involves the transformation of physiological tau into pathogenic tau. One of the prime causes reported to drive this conversion is tau hyperphosphorylation and the subsequent propagation of… read more here.
Keywords: propagation; tau; age dependent; human tau ... See more keywords
Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-020-20322-w
Abstract: Microtubule-associated protein Tau can form protein aggregates transmissible within the brain, correlating with the progression of tauopathies in humans. The transmission of aggregates requires neuron-released Tau to interact with surface receptors on target cells. However,… read more here.
Keywords: recombinant human; tau; filamentous recombinant; human tau ... See more keywords
Mice expressing P301S mutant human tau have deficits in interval timing
Sign Up to like & getrecommendations! Published in 2022 at "Behavioural Brain Research"
DOI: 10.1101/2022.04.04.487032
Abstract: Interval timing is a key executive process that involves estimating the duration of an interval over several seconds or minutes. Patients with Alzheimer’s disease (AD) have deficits in interval timing. Since temporal control of action… read more here.
Keywords: timing; interval timing; mice; human tau ... See more keywords
Maintained memory and long‐term potentiation in a mouse model of Alzheimer's disease with both amyloid pathology and human tau
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.14918
Abstract: One of the key knowledge gaps in the field of Alzheimer's disease research is the lack of understanding of how amyloid beta and tau cooperate to cause neurodegeneration. We recently generated a mouse model (APP/PS1… read more here.
Keywords: tau; human tau; alzheimer disease; pathology ... See more keywords
Role of tau N-terminal motif in the secretion of human tau by End Binding proteins
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DOI: 10.1371/journal.pone.0210864
Abstract: For unknown reasons, humans appear to be particular susceptible to developing tau pathology leading to neurodegeneration. Transgenic mice are still undoubtedly the most popular and extensively used animal models for studying Alzheimer's disease and other… read more here.
Keywords: end binding; motif; tau; binding proteins ... See more keywords
Human Tau Isoforms and Proteolysis for Production of Toxic Tau Fragments in Neurodegeneration
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2021.702788
Abstract: The human tau protein is implicated in a wide range of neurodegenerative “tauopathy” diseases, consisting of Alzheimer’s disease (AD) and frontotemporal lobar degeneration which includes progressive supranuclear palsy, corticobasal degeneration, Pick’s disease, and FTLD-tau (frontotemporal… read more here.
Keywords: tau; toxic tau; human tau; tau fragments ... See more keywords
Hyperphosphorylated Human Tau Accumulates at the Synapse, Localizing on Synaptic Mitochondrial Outer Membranes and Disrupting Respiration in a Mouse Model of Tauopathy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.852368
Abstract: Neurogenerative disorders, such as Alzheimer’s disease (AD), represent a growing public health challenge in aging societies. Tauopathies, a subset of neurodegenerative disorders that includes AD, are characterized by accumulation of fibrillar and hyperphosphorylated forms of… read more here.
Keywords: synaptic mitochondrial; tau; tau accumulates; hyperphosphorylated human ... See more keywords
Differential Effects of Human Tau Isoforms to Neuronal Dysfunction and Toxicity in the Drosophila CNS
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232112985
Abstract: Accumulation of highly post-translationally modified tau proteins is a hallmark of neurodegenerative disorders known as tauopathies, the most common of which is Alzheimer’s disease. Although six tau isoforms are found in the human brain, the… read more here.
Keywords: tau; tau isoforms; neuronal dysfunction; dysfunction toxicity ... See more keywords