LAUSR

Quantum Mechanical Investigation of the G-Quadruplex Systems of Human Telomere

Sign Up to like & get
recommendations!
0 Published in 2018 at "ACS Omega"

DOI: 10.1021/acsomega.8b01678

Abstract: The three G-quadruplexes involved in the human telomere have been studied with an accurate quantum mechanical approach, and the possibility of reducing them to a simpler model has been tested. The similarities and the differences… read more here.

Keywords: investigation quadruplex; quadruplex systems; mechanical investigation; cavity ... See more keywords

Absorption of Low-Energy UV Radiation by Human Telomere G-Quadruplexes Generates Long-Lived Guanine Radical Cations.

Sign Up to like & get
recommendations!
0 Published in 2017 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.7b05931

Abstract: Telomeres, which are involved in cell division, carcinogenesis, and aging and constitute important therapeutic targets, are prone to oxidative damage. This propensity has been correlated with the presence of guanine-rich sequences, capable of forming four-stranded… read more here.

Keywords: absorption; telomere quadruplexes; human telomere; radical cations ... See more keywords

Dynamics of TRF1 organizing a single human telomere

Sign Up to like & get
recommendations!
1 Published in 2020 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkaa1222

Abstract: Abstract Chromosome stability is primarily determined by telomere length. TRF1 is the core subunit of shelterin that plays a critical role in telomere organization and replication. However, the dynamics of TRF1 in scenarios of telomere-processing… read more here.

Keywords: dynamics trf1; dna; trf1 organizing; fork ... See more keywords

i-Motif of cytosine-rich human telomere DNA fragments containing natural base lesions

Sign Up to like & get
recommendations!
0 Published in 2018 at "Nucleic Acids Research"

DOI: 10.1093/nar/gky035

Abstract: Abstract i-Motif (iM) is a four stranded DNA structure formed by cytosine-rich sequences, which are often present in functionally important parts of the genome such as promoters of genes and telomeres. Using electronic circular dichroism… read more here.

Keywords: dna; telomere dna; base lesions; cytosine rich ... See more keywords

Replication Control of Human Telomere G-Quadruplex DNA by G-Quadruplex Ligands Dependent on Solution Environment

Sign Up to like & get
recommendations!
1 Published in 2022 at "Life"

DOI: 10.3390/life12040553

Abstract: The human telomere region is known to contain guanine-rich repeats and form a guanine-quadruplex (G4) structure. As telomeres play a role in the regulation of cancer progression, ligands that specifically bind and stabilize G4 have… read more here.

Keywords: topology; solution environment; dna; replication ... See more keywords