Haplotype diversity and sequence heterogeneity of human telomeres.
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DOI: 10.1101/gr.274639.120
Abstract: Telomeres are regions of repetitive nucleotide sequences capping the ends of eukaryotic chromosomes that protect against deterioration, and whose lengths can be correlated with age and adverse health risk factors. Yet, given their length and… read more here.
Keywords: human telomeres; heterogeneity human; diversity; sequence ... See more keywords
Molecular Recognition of the Hybrid-Type G-Quadruplexes in Human Telomeres
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DOI: 10.3390/molecules24081578
Abstract: G-quadruplex (G4) DNA secondary structures formed in human telomeres have been shown to inhibit cancer-specific telomerase and alternative lengthening of telomere (ALT) pathways. Thus, human telomeric G-quadruplexes are considered attractive targets for anticancer drugs. Human… read more here.
Keywords: human telomeres; human telomeric; small molecule; telomeric quadruplexes ... See more keywords