Effect of structure levels on surface-enhanced Raman scattering of human telomeric G-quadruplexes in diluted and crowded media
Sign Up to like & getrecommendations! Published in 2019 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-019-01894-z
Abstract: AbstractHuman telomeric G-quadruplexes are emerging targets in anticancer drug discovery since they are able to efficiently inhibit telomerase, an enzyme which is greatly involved in telomere instability and immortalization process in malignant cells. G-quadruplex (G4)… read more here.
Keywords: human telomeric; surface enhanced; raman scattering; enhanced raman ... See more keywords
G-quadruplex structures formed by human telomeric DNA and C9orf72 hexanucleotide repeats
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical Reviews"
DOI: 10.1007/s12551-019-00545-y
Abstract: DNA or RNA strands that are composed stretches of guanines (G-tracts) divided by other bases are able to form Gquadruplexes, a tetra-helical structure with stacked G-tetrad planes connected by Hoogsteen hydrogen bonds and stabilized by… read more here.
Keywords: structures formed; human telomeric; dna; telomeric dna ... See more keywords
Human telomeric hybrid-2-over-hybrid-1 G-quadruplex targeting and a selective hypersaline-tolerant sensor using abasic site-engineered monomorphism.
Sign Up to like & getrecommendations! Published in 2017 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2017.01.041
Abstract: Coexistence of the polymorphic hybrid-1 and hybrid-2 conformers for a given human telomeric G-quadruplex-forming sequence (htG4) complicates its fine structure identification and limits its application as a sensor element. With help from abasic site (AP… read more here.
Keywords: human telomeric; hybrid hybrid; site; abasic site ... See more keywords
Spectroscopic and molecular docking studies for the binding and interaction aspects of curcumin-cysteine conjugate and rosmarinic acid with human telomeric G-quadruplex DNA.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.05.089
Abstract: The binding and interaction aspects of potential anticancer ligands like: curcumin-cysteine (CC) and rosmarinic acid (RA) with human telomeric G-quadruplex DNA, a novel anticancer target, have been probed by spectroscopic and molecular docking approach. The… read more here.
Keywords: quadruplex dna; human telomeric; spectroscopic molecular; telomeric quadruplex ... See more keywords
Exploring the Dynamics of Propeller Loops in Human Telomeric DNA Quadruplexes Using Atomistic Simulations
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Chemical Theory and Computation"
DOI: 10.1021/acs.jctc.7b00226
Abstract: We have carried out a series of extended unbiased molecular dynamics (MD) simulations (up to 10 μs long, ∼162 μs in total) complemented by replica-exchange with the collective variable tempering (RECT) approach for several human… read more here.
Keywords: propeller loops; human telomeric; force field; telomeric dna ... See more keywords
Structural Dynamics of Lateral and Diagonal Loops of Human Telomeric G-Quadruplexes in Extended MD Simulations.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of chemical theory and computation"
DOI: 10.1021/acs.jctc.8b00543
Abstract: The NMR solution structures of human telomeric (Htel) G-quadruplexes (GQs) are characterized by the presence of two lateral loops complemented by either diagonal or propeller loops. Bases of a given loop can establish interactions within… read more here.
Keywords: human telomeric; diagonal loops; dynamics lateral; lateral diagonal ... See more keywords
Pyridine Derivative of the Natural Alkaloid Berberine as Human Telomeric G4-DNA Binder: A Solution and Solid-State Study.
Sign Up to like & getrecommendations! Published in 2020 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.9b00516
Abstract: Telomerase is an enzyme deputed to the maintenance of eukaryotic chromosomes; however, its overexpression is a recognized hallmark of many cancer forms. A viable route for the inhibition of telomerase in malignant cells is the… read more here.
Keywords: human telomeric; berberine human; natural alkaloid; pyridine derivative ... See more keywords
Stabilization of human telomeric RNA G-quadruplex by the water-compatible optically pure and biologically-active metallohelices
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-71429-5
Abstract: RNA G-quadruplexes have been suggested to play key roles in fundamental biological processes and are linked to human diseases. Thus, they also represent good potential therapeutic targets. Here, we describe, using the methods of molecular… read more here.
Keywords: human telomeric; stabilization; rna; telomeric rna ... See more keywords
Binding properties of mono- and dimeric pyridine dicarboxamide ligands to human telomeric higher-order G-quadruplex structures.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c7cc07048a
Abstract: Here, we report on the in vitro binding properties of the known pyridine dicarboxamide G-quadruplex ligand 360A and a new dimeric analogue (360A)2A to human telomeric DNA higher-order G-quadruplex (G4) structures. This study points to… read more here.
Keywords: human telomeric; pyridine dicarboxamide; order quadruplex; higher order ... See more keywords
A chair-type G-quadruplex structure formed by a human telomeric variant DNA in K+ solution† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc03813a
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Science"
DOI: 10.1039/c8sc03813a
Abstract: The chair-type G-quadruplex structure formed by human telomeric variant DNA. read more here.
Keywords: chair type; human telomeric; quadruplex structure; structure formed ... See more keywords
Two novel fan-shaped trinuclear Pt(ii) complexes act as G-quadruplex binders and telomerase inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "Dalton transactions"
DOI: 10.1039/d0dt01767a
Abstract: Two new trinuclear Pt(ii) complexes {[Pt(dien)]3(tib)}(NO3)6 (1) and {[Pt(dpa)]3(tib)}(NO3)6 (2) (dien: diethylenetriamine, dpa: bis-(2-pyridylmethyl)amine, tib: 1,3,5-tris(1H-imidazol-1-yl)benzene) have been designed, synthesized, characterized and applied to a series of biochemical studies. We found that both of the… read more here.
Keywords: human telomeric; fan shaped; quadruplex; shaped trinuclear ... See more keywords