Elucidating the Therapeutic Potential of Cell-Penetrating Peptides in Human Tenon Fibroblast Cells
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DOI: 10.1021/acsomega.2c00701
Abstract: Cell-penetrating peptides (CPPs) have been widely used as vehicles for delivering therapeutic molecules to the site of action. Apart from their delivering potential, the biological effects of CPPs have not been explored in detail. JTS-1… read more here.
Keywords: cell; human tenon; cell penetrating; penetrating peptides ... See more keywords
TGF-β1 Induces Human Tenon’s Fibroblasts Fibrosis via miR-200b and Its Suppression of PTEN Signaling
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DOI: 10.1080/02713683.2018.1549261
Abstract: ABSTRACT Background: To determine the involvement of MicroRNA-200b (miR-200b) in human Tenon’s fibroblasts (HTFs) fibrosis. Methods: HTFs were treated with 10 ng/ml TGF-β1 for 24 h. Expression of α-smooth muscle actin (α-SMA), Fibronectin and Collagen1A1… read more here.
Keywords: mir; human tenon; mir 200b; pten signaling ... See more keywords
The Effect of Irradiated Riboflavin in Human Tenon's Fibroblast - A Study on Cellular Viability.
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DOI: 10.1080/02713683.2021.2011326
Abstract: PURPOSE/ AIM The main purpose of this work is to study the cellular viability effect of irradiated riboflavin in cultured human tenon fibroblasts. MATERIALS AND METHODS The tenon tissue was harvested from a patient undergoing… read more here.
Keywords: human tenon; tenon fibroblast; cellular viability; irradiated riboflavin ... See more keywords
Dihydroartemisinin Inhibits TGF-β-Induced Fibrosis in Human Tenon Fibroblasts via Inducing Autophagy
Sign Up to like & getrecommendations! Published in 2021 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s280322
Abstract: Background The formation of hypertrophic scars (HS) can result in the failure of glaucoma surgery, and fibrosis is known to be closely associated with the progression of HS. Dihydroartemisinin (DHA) has been reported to inhibit… read more here.
Keywords: human tenon; induced fibrosis; fibrosis; inducing autophagy ... See more keywords
MEK inhibition prevents TGF-β1-induced myofibroblast transdifferentiation in human tenon fibroblasts
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2018.9673
Abstract: Subconjunctival fibrosis represents the primary cause of postoperative failure of trabeculectomy, and at present there is a lack of effective intervention strategies. The present study aimed to investigate the effect of the mitogen-activated protein kinase… read more here.
Keywords: transdifferentiation; kinase; inhibition; human tenon ... See more keywords