Identifying the inheritable component of human thymic T cell repertoire generation in monozygous twins
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Immunology"
DOI: 10.1002/eji.201948404
Abstract: We have analyzed T cell receptor repertoires in a unique set of thymus samples from a pair of monozygotic twins. While genetics affect the V(D)J rearrangement and generation of junctional sequences, the thymic selections seem… read more here.
Keywords: component human; inheritable component; identifying inheritable; generation ... See more keywords
Multimodal human thymic profiling reveals trajectories and cellular milieu for T agonist selection
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1092028
Abstract: To prevent autoimmunity, thymocytes expressing self-reactive T cell receptors (TCRs) are negatively selected, however, divergence into tolerogenic, agonist selected lineages represent an alternative fate. As thymocyte development, selection, and lineage choices are dependent on spatial… read more here.
Keywords: thymic profiling; cell; multimodal human; human thymic ... See more keywords
CD90 Marks a Mesenchymal Program in Human Thymic Epithelial Cells In Vitro and In Vivo
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.846281
Abstract: Thymic epithelium is critical for the structural integrity of the thymus and for T cell development. Within the fully formed thymus, large numbers of hematopoietic cells shape the thymic epithelium into a scaffold-like structure which… read more here.
Keywords: cd90; cell; thymic epithelial; human thymic ... See more keywords