Intrinsic Fluorescence of the Active and the Inactive Functional Forms of Human Thymidylate Synthase
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DOI: 10.1002/cbic.202000722
Abstract: The observables associated with protein intrinsic fluorescence – spectra, time decays, anisotropies – offer opportunities to monitor in real time and non‐invasively a protein‘s functional form and its interchange with other forms with different functions.… read more here.
Keywords: active inactive; forms human; fluorescence; human thymidylate ... See more keywords
Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth.
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DOI: 10.1021/acs.jmedchem.7b01699
Abstract: LR and [d-Gln4]LR peptides bind the monomer-monomer interface of human thymidylate synthase and inhibit cancer cell growth. Here, proline-mutated LR peptides were synthesized. Molecular dynamics calculations and circular dichroism spectra have provided a consistent picture… read more here.
Keywords: cell growth; thymidylate synthase; human thymidylate; cancer cell ... See more keywords
Biomolecular study of human thymidylate synthase conformer-selective inhibitors: New chemotherapeutic approach
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DOI: 10.1371/journal.pone.0193810
Abstract: Thymidylate synthase (TS) is a well-validated target for the therapy of adult cancers. Propane-1,3-diphosphonic acid (PDPA) has significant inhibitory properties against human thymidylate synthase (hTS) relative to mouse TS which is not predicted to adopt… read more here.
Keywords: synthase; conformer; thymidylate synthase; human thymidylate ... See more keywords