Modeling Human Thyroid Development by Fetal Tissue‐Derived Organoid Culture
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202105568
Abstract: Abstract Euthyroidism is of profound importance for lifetime health. However, the early diagnosis or therapeutics of thyroid developmental defects has not been established, mainly due to limited understanding of human thyroid development and a lack… read more here.
Keywords: culture; fetal thyroid; thyroid development; thyroid ... See more keywords
Primary 3D Culture of Human Thyroid Follicle-Like Structures in Platelet Lysate-Based Gel
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DOI: 10.1007/s10517-020-04930-6
Abstract: The results of 3D culturing of human thyroid follicle-like structures in a gel based on platelet lysate at the gel-air interface are presented. During culturing up to 4 months, no new follicle-like structures were formed… read more here.
Keywords: human thyroid; follicle like; like structures; thyroid follicle ... See more keywords
Radiosensitivity enhancement of human thyroid carcinoma cells by the inhibitors of histone deacetylase sodium butyrate and valproic acid
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2018.08.007
Abstract: Radiotherapy is one of the leading treatments for clinical cancer therapy. External beam radiotherapy has been proposed as an adjuvant treatment for patients bearing differentiated thyroid cancer refractory to conventional therapy. Our purpose was to… read more here.
Keywords: human thyroid; radiosensitivity; thyroid cancer; thyroid ... See more keywords
Honokiol, a potential therapeutic agent, induces cell cycle arrest and program cell death in vitro and in vivo in human thyroid cancer cells
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DOI: 10.1016/j.phrs.2016.11.038
Abstract: Graphical abstract Figure. No caption available. ABSTRACT Thyroid cancer is the most common endocrine malignancy, the global incidence rate of which is rapidly rising. Surgery and radioiodine therapies are common and effective treatments only for… read more here.
Keywords: human thyroid; thyroid cancer; cancer cells; cancer ... See more keywords
Thyroid-Disrupting Effects of Exposure to Fipronil and Its Metabolites from Drinking Water Based on Human Thyroid Follicular Epithelial Nthy-ori 3-1 Cell Lines.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental science & technology"
DOI: 10.1021/acs.est.2c08627
Abstract: Fipronil is a broad-spectrum insecticide used for plants and poultry. Owing to its widespread use, fipronil and its metabolites (fipronil sulfone, fipronil desulfinyl, and fipronil sulfide), termed FPM, can be frequently detected in drinking water… read more here.
Keywords: drinking water; nthy ori; fipronil; thyroid ... See more keywords
Morphologic evidence of telocytes in human thyroid stromal tissue
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DOI: 10.1111/jcmm.17282
Abstract: Despite the evidence accumulated over the past decade that telocytes (TCs) are a distinctive, though long neglected, cell entity of the stromal microenvironment of several organs of the human body, to date their localization in… read more here.
Keywords: thyroid stromal; human thyroid; microscopy; stromal tissue ... See more keywords
Genetics of Human Thyroid Cancer Cell Lines—Letter
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DOI: 10.1158/1078-0432.ccr-19-2107
Abstract: We read with great interest the article by Landa and colleagues that reported the comprehensive genetic characterization of 60 human thyroid cancer cell lines ([1][1]). Molecular driver alterations, similar to known genomic defects in human… read more here.
Keywords: human thyroid; genetics; thyroid cancer; cancer cell ... See more keywords
Genetics of Human Thyroid Cancer Cell Lines—Response
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-19-2531
Abstract: We read with interest the letter by Garcia and colleagues, as well as their recent publication assessing MET amplification in the anaplastic thyroid cancer (ATC)-derived TTA-1 cell line ([1][1]). In their correspondence, the authors asked… read more here.
Keywords: genetics human; human thyroid; cancer; genetics ... See more keywords
A molecular view of the normal human thyroid structure and function reconstructed from its reference transcriptome map
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DOI: 10.1186/s12864-017-4049-z
Abstract: BackgroundThe thyroid is the earliest endocrine structure to appear during human development, and thyroid hormones are necessary for proper organism development, in particular for the nervous system and heart, normal growth and skeletal maturation. To… read more here.
Keywords: human thyroid; reference; physiology; expression ... See more keywords
Single cell analysis of human thyroid reveals the transcriptional signatures of aging.
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DOI: 10.1210/endocr/bqad029
Abstract: The thyroid gland plays a critical role in the maintenance of whole body metabolism. However, aging frequently impairs homeostatic maintenance by thyroid hormones due to increased prevalence of subclinical hypothyroidism associated with mitochondrial dysfunction, inflammation,… read more here.
Keywords: cell; thyroid; human thyroid; thyroid gland ... See more keywords
Cryo-electron microscopy structures of human thyroid peroxidase (TPO) in complex with TPO antibodies
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Endocrinology"
DOI: 10.1530/jme-22-0149
Abstract: Determination of the structure of the extracellular domain of human thyroid peroxidase (hTPO) by cryo-electron microscopy (cryo-EM) is described. TPO, purified to homogeneity was complexed with the hTPO monoclonal autoantibody 2G4 Fab and also with… read more here.
Keywords: human thyroid; tpo; microscopy; domain ... See more keywords