Effects of Small Conductance Ca2+‐Activated Potassium Channel Agonists on SLEs in Varied Epilepsy Models, From Animal Slices to Pharmacoresistant Human Tissue
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.70078
Abstract: To assess the impact of SK channel agonists on seizure‐like events (SLEs) in various seizure models in slices of the temporal cortex obtained from pharmacoresistant patients. SLEs were triggered by applying 4‐aminopyridine (100 μM) to slices… read more here.
Keywords: epilepsy; channel agonists; human tissue; cortex ... See more keywords
Technical Note: Human tissue-equivalent MRI phantom preparation for 3 and 7 Tesla.
Sign Up to like & getrecommendations! Published in 2021 at "Medical physics"
DOI: 10.1002/mp.14986
Abstract: PURPOSE While test objects (phantoms) in MRI are crucial for sequence development, protocol validation and quality control, studies on the preparation of phantoms has been scarce, particularly at fields exceeding 3 Tesla. Here we present… read more here.
Keywords: human tissue; technical note; tissue; note human ... See more keywords
Optical Sensor for Real-Time pH Monitoring in Human Tissue.
Sign Up to like & getrecommendations! Published in 2018 at "Small"
DOI: 10.1002/smll.201803627
Abstract: This article reports on a fiber-based ratiometric optical pH sensor for use in real-time and continuous in vivo pH monitoring in human tissue. Stable hybrid sol-gel-based pH sensing material is deposited on a highly flexible… read more here.
Keywords: human tissue; real time; time; monitoring human ... See more keywords
A subcellular cookie cutter for spatial genomics in human tissue
Sign Up to like & getrecommendations! Published in 2022 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-022-03944-5
Abstract: Intracellular heterogeneity contributes significantly to cellular physiology and, in a number of debilitating diseases, cellular pathophysiology. This is greatly influenced by distinct organelle populations and to understand the aetiology of disease, it is important to… read more here.
Keywords: tissue; cutter spatial; subcellular biopsy; subcellular cookie ... See more keywords
Is it safe to use bone tissue for transplants stored for more than five years in a human tissue bank?
Sign Up to like & getrecommendations! Published in 2025 at "Cell and Tissue Banking"
DOI: 10.1007/s10561-025-10185-0
Abstract: Human Tissue Banks (BTH) must validate the storage of collected/processed tissues ensuring physical integrity, sterility, and microbial protection for up to 5 years. (1) Is it safe to use bone tissue for transplants collected by… read more here.
Keywords: safe use; bone tissue; packaging; tissue ... See more keywords
ATAC-ing human tissue Treg cells.
Sign Up to like & getrecommendations! Published in 2021 at "Immunity"
DOI: 10.1016/j.immuni.2021.03.014
Abstract: What defines regulatory T (Treg) cells in healthy human tissues? In this issue of Immunity, Delacher et al. describe a human follicular helper T cell-like tissue-repair Treg cell signature governed by BATF based on chromatin accessibility data… read more here.
Keywords: human tissue; treg cells; atac ing; ing human ... See more keywords
Structure-Activity Relationships of Potent, Targeted Covalent Inhibitors That Abolish Both the Transamidation and GTP Binding Activities of Human Tissue Transglutaminase.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b01070
Abstract: Human tissue transglutaminase (hTG2) is a multifunctional enzyme. It is primarily known for its calcium-dependent transamidation activity that leads to formation of an isopeptide bond between glutamine and lysine residues found on the surface of… read more here.
Keywords: human tissue; targeted covalent; tissue transglutaminase; gtp binding ... See more keywords
Development of an iPSC-derived tissue-resident macrophage-based platform for the in vitro immunocompatibility assessment of human tissue engineered matrices
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-62745-1
Abstract: Upon implanting tissue-engineered heart valves (TEHVs), blood-derived macrophages are believed to orchestrate the remodeling process. They initiate the immune response and mediate the remodeling of the TEHV, essential for the valve’s functionality. The exact role… read more here.
Keywords: tissue engineered; immunocompatibility; ipsc derived; tissue resident ... See more keywords
Comprehensive identification of alternative back-splicing in human tissue transcriptomes
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa005
Abstract: Abstract Circular RNAs (circRNAs) are covalently closed RNAs derived from back-splicing of genes across eukaryotes. Through alternative back-splicing (ABS), a single gene produces multiple circRNAs sharing the same back-splice site. Although many ABS events have… read more here.
Keywords: human tissue; alternative back; back splicing; tissue transcriptomes ... See more keywords
Animal models and human tissue compared to better understand and treat the epilepsies
Sign Up to like & getrecommendations! Published in 2023 at "Epilepsia"
DOI: 10.1111/epi.17552
Abstract: Animal models of human brain disorders permit researchers to explore disease mechanisms and to test potential therapies. However, therapeutic molecules derived from animal models often translate poorly to the clinic. Although human data may be… read more here.
Keywords: models human; animal models; tissue compared; epilepsies animal ... See more keywords
Intraoperative hyperspectral determination of human tissue properties
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biomedical Optics"
DOI: 10.1117/1.jbo.23.9.091409
Abstract: Abstract. We address the automatic differentiation of human tissue using multispectral imaging with promising potential for automatic visualization during surgery. Currently, tissue types have to be continuously differentiated based on the surgeon’s knowledge only. Further,… read more here.
Keywords: human tissue; tissue types; intraoperative hyperspectral; hyperspectral determination ... See more keywords